Document Detail


Application of the margin-of-exposure (MoE) approach to substances in food that are genotoxic and carcinogenic e.g.: benzo[a]pyrene and polycyclic aromatic hydrocarbons.
MedLine Citation:
PMID:  19818825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Benzo[a]pyrene (BaP) and a number of other polycyclic aromatic hydrocarbons (PAH) are mutagenic and are also carcinogenic in rodent bioassays. Oral carcinogenicity data are not available for individual PAH other than BaP, and so BaP has been used as a marker of the carcinogenicity of, and exposure to, PAHs. Carcinogenicity studies of coal tar mixtures, considered to be representative of the genotoxic and carcinogenic PAH in food, have been used for dose-response modelling. Modelling the number of tumour-bearing mice resulted in a BMDL(10) of 0.122 mg BaP/kg-bw/day, which was lower than that for any of the individual tumours and was considered to be most appropriate since the different PAH may have different mechanisms of carcinogenicity. An average dietary exposure estimates of 0.008 microg BaP/kg-bw/day was identified from the range of national estimates. The calculated MoE was 15,000.
Authors:
Diane Benford; Michael Dinovi; R Woodrow Setzer
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-10-08
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48 Suppl 1     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S42-8     Citation Subset:  IM    
Copyright Information:
Crown Copyright 2010. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Food Standards Agency, UK. publications@ilsieurope.be
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzo(a)pyrene / toxicity*
Carcinogens / toxicity*
Data Interpretation, Statistical
Diet
Dose-Response Relationship, Drug
Female
Food Contamination / analysis*
Humans
Male
Mice
Models, Statistical
Mutagens / toxicity*
Neoplasms / chemically induced,  epidemiology
Polycyclic Hydrocarbons, Aromatic / toxicity*
Rats
Chemical
Reg. No./Substance:
0/Carcinogens; 0/Mutagens; 0/Polycyclic Hydrocarbons, Aromatic; 50-32-8/Benzo(a)pyrene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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