| Application of laccase-mediator system (LMS) for the degradation of organophosphorus compounds. | |
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MedLine Citation:
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PMID: 20149786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Degradation of organophosphorus compounds was achieved in the presence of purified fungal laccase from Trametes versicolor and a small molecular weight redox mediator (ABTS). This laccase-mediator system (LMS) catalyzed degradation of VX, PhX and VR while had no apparent effect on CVX, ecothiophate or demeton. Inhibition of ABTS oxidation was shown with VX, PhX, VR and CVX. Results with CVX suggest either no degradation subsequent to interaction with the laccase active site or the formation of a new toxic compound. PhX degradation was also monitored by mass spectroscopy, a method that allowed us to identify certain intermediates formed during OP degradation. Altogether, results underline the importance of the OP nitrogen atom at beta-position and of its substituents, even though the intimate mechanism of laccase-catalyzed degradation is not yet known. |
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Authors:
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Marie Trovaslet-Leroy; Claude Jolivalt; Marie-Thérèse Froment; Bernardin Brasme; Bertrand Lefebvre; Denis Daveloose; Florian Nachon; Patrick Masson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-10 |
Journal Detail:
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Title: Chemico-biological interactions Volume: 187 ISSN: 1872-7786 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: Ireland |
Other Details:
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Languages: eng Pagination: 393-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Département de Toxicologie, Centre de Recherches du Service de Santé des Armées (CRSSA), 24 Avenue des maquis du Grésivaudan, 38702 La Tronche Cedex, France. mtrovaslet@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biotransformation Laccase / metabolism* Mass Spectrometry Organophosphorus Compounds / metabolism*, toxicity Oxidation-Reduction Trametes / enzymology |
| Chemical | |
Reg. No./Substance:
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0/Organophosphorus Compounds; EC 1.10.3.2/Laccase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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