Document Detail

Application of the HALF index obviates the need for liver biopsy in half of all patients with chronic hepatitis B.
MedLine Citation:
PMID:  21198828     Owner:  NLM     Status:  Publisher    
Background and Aims: Transient elastography (TE) is useful for predicting the fibrosis stage, but it is unsatisfactory substitutes for liver biopsy, especially in patients with chronic hepatitis B (CHB). This study was performed to establish a reliable model for predicting significant fibrosis (SF) in patients with CHB. Methods: All CHB patients who were admitted to undergo liver biopsy were enrolled. They were randomly classified into either a training set (n=139) or a validation set (n=69). A model for predicting SF was established in the training set and validated in the validation set. Low and high cutoff values (COVs) were chosen for sensitivity ≥99% and specificity ≥99%, respectively. Results: A total of 208 patients were enrolled. Age was 39±12 years and 149 (71.6%) were men. In the training set, liver stiffness values and serum haptoglobin, apolipoprotein A1, and α2-macroglobulin levels were independent predictors of SF on multivariate analysis. These variables were used to construct a novel model, called the HALF index. The area under the receiver operating characteristics curve of the HALF index for predicting SF was significantly higher than that of TE alone (0.915 vs 0.877, P=0.010). Using low and high COVs of the HALF index, it appears that approximately half (47.1%) of patients could avoid liver biopsy, with an associated accuracy of 99.0%. Conclusion: A combination of liver stiffness and serum markers identified SF with a high degree of accuracy. Approximately half of all patients with CHB could avoid liver biopsy through the utilization of the HALF index.
Hyun Jung Lee; Yeon Seok Seo; Dong Jin Kim; Hyun Seok Kang; Hyonggin An; Ji Hoon Kim; Jae Youn Cheong; Hyung Joon Yim; Jong Eun Yeon; Hong Sik Lee; Kwan Soo Byun; Sung Won Cho; Dong Joon Kim; Soon Ho Um; Chang Duck Kim; Ho Sang Ryu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-28
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea; Department of Biostatistics, Korea University College of Medicine, Seoul, Korea; Department of Internal Medicine, Ajou University School of Medicine, Suwon, Korea; Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
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