| Application of drag-reducing polymer solutions as test fluids for in vitro evaluation of potential blood damage in blood pumps. | |
| | |
MedLine Citation:
|
PMID: 20019596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In vitro evaluation of the potential of a circulatory-assist device to damage blood cells has generally been performed using blood from various species. Problems with this approach include the variability of blood sensitivity to mechanical stress in different species, preparation of blood including the adjustment of hematocrit to a standard value, changes in the mechanical properties of blood that occur during storage, and necessity to pool blood samples to obtain an adequate amount of blood for in vitro circulating systems. We investigated whether the mechanical degradation of a drag-reducing polymer (DRP) solution resulting in the loss of drag-reducing ability can indicate the degree of shear-induced blood damage within blood pumps. DRP solution (polyethylene oxide, 4,500 kDa, 1,000 ppm) or porcine blood were driven through a turbulent flow system by a centrifugal pump, either the Bio-Pump BPX-80 (Medtronic, Inc.) or CentriMag (Levitronix LLC) at a constant pressure gradient of 300 mm Hg for 120 minutes. DRP mechanical degradation was evaluated by reduction of flow rate and solution viscosity. A proposed index of DRP mechanical degradation (PDI) is similar to the normalized index of hemolysis (NIH) typically used to quantify the results of in vitro testing of blood pumps. Results indicate that the mechanical degradation of DRP solutions may provide a sensitive standard method for the evaluation of potential blood trauma produced by blood pumps without the use of blood. |
| | |
Authors:
|
Amanda R Daly; Hideo Sobajima; Salim E Olia; Setsuo Takatani; Marina V Kameneva |
Related Documents
:
|
10999376 - Performance of enlarged blood pump models with five different impellers. 14653416 - History of extracorporeal circulation: the conceptional and developmental period. 20642766 - Long-term continuous flow left ventricular assist device support and end-organ function... 2252746 - Physiologic reactions of awake animals to an immediate switch from a pulsatile to nonpu... 10999376 - Performance of enlarged blood pump models with five different impellers. 6735606 - A comparison of the technetium-labeled myocardial agents diars and dmpe to 201tl in exp... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 56 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2010 Jan-Feb |
Date Detail:
|
Created Date: 2010-01-14 Completed Date: 2010-03-09 Revised Date: 2011-07-20 |
Medline Journal Info:
|
Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
|
Languages: eng Pagination: 6-11 Citation Subset: IM |
Affiliation:
|
McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Heart-Assist Devices / adverse effects* Polyethylene Glycols* Rheology / methods* Stress, Mechanical* Swine |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL089456-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Polyethylene Glycols |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Numerical Study of a Centrifugal Blood Pump With Different Impeller Profiles.
Next Document: Noninvasive Predictor of HeartMate XVE Pump Failure by Neural Network and Waveform Analysis.