Document Detail

Application of the Dietary Reference Intakes in developing a recommendation for pregnancy iron supplements in Canada.
MedLine Citation:
PMID:  19692491     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: For many pregnant Canadian women, usual iron intakes from food appear to be inadequate compared with Dietary Reference Intake requirement estimates. OBJECTIVE: Dietary intake modeling was undertaken to determine an amount of iron supplementation that would confer acceptably low prevalence of apparently inadequate and apparently excessive intakes. DESIGN: The distribution of usual dietary iron intakes was estimated with the use of 24-h recalls from pregnant women aged 19-50 y in the Canadian Community Health Survey, Cycle 2.2. The prevalence of usual intakes below the Estimated Average Requirement for pregnancy (22 mg/d) or above the Tolerable Upper Intake Level (45 mg/d) was estimated. Iterative modeling with incremental iron supplement was performed to determine a suitable supplement amount. Because the sample of pregnant women was small (148 day 1 recalls), estimates of the tails of the distributions had large SDs, and supporting analyses based on intake data from nonpregnant women (4540 day 1 recalls) were made. RESULTS: Daily supplementation shifted the intake distribution curve without changing its shape. Supplementation with 16 mg iron/d was consistent with low (<3%) prevalence of apparently inadequate intakes. This amount of supplementation should not be associated with an increase in apparently excessive intakes by pregnant women in this population. CONCLUSIONS: On the basis of Dietary Reference Intakes, an iron supplement of 16 mg/d throughout pregnancy is justified as both efficacious and safe for healthy women living in Canadian households. This does not preclude the need for therapeutic iron doses for some individuals on the basis of iron status. The method can be applied to other populations if suitable baseline iron intake data are available.
Kevin A Cockell; Doris C Miller; Hélène Lowell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-19
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1023-8     Citation Subset:  AIM; IM    
Nutrition Research Division, Food Directorate and the Office of Nutrition Policy and Promotion, Health Products and Food Branch, Health Canada, Ottawa, Canada.
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MeSH Terms
Anemia, Iron-Deficiency / drug therapy*,  epidemiology
Canada / epidemiology
Diet Records
Dietary Supplements*
Guidelines as Topic
Iron / administration & dosage*,  adverse effects,  therapeutic use
Iron, Dietary / administration & dosage*,  adverse effects
Middle Aged
Models, Biological
Nutrition Policy
Nutritional Requirements*
Reference Values
Young Adult
Reg. No./Substance:
0/Iron, Dietary; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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