| Application of 15N nuclear magnetic resonance spectroscopy to the determination of the stability of aryl nitrogen mustards. | |
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MedLine Citation:
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PMID: 7783158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An excellent correlation has been shown to exist between the 15N NMR chemical shifts of a series of aryl nitrogen mustards and the Hammett constant, sigma, which is much improved by the use of sigma-. These chemical shifts also correlate well with the hydrolysis rates of the compounds in 50% aqueous acetone at 66 degrees C and their alkylation of 4-(4'-nitrobenzyl)pyridine under similar conditions. Thus 15N NMR is a straightforward and material-conserving method for estimating the relative stabilities of aryl nitrogen mustards. |
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Authors:
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D E Wilman; B D Palmer; W A Denny |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 38 ISSN: 0022-2623 ISO Abbreviation: J. Med. Chem. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-07-14 Completed Date: 1995-07-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2256-8 Citation Subset: IM |
Affiliation:
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Cancer Research Campaign Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Stability Hydrolysis Kinetics Magnetic Resonance Spectroscopy Nitrogen Isotopes Nitrogen Mustard Compounds / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Isotopes; 0/Nitrogen Mustard Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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