| Applicability of near-infrared spectroscopy to measure cerebral autoregulation non-invasively in neonates: a validation study in piglets. | |
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MedLine Citation:
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PMID: 21566541 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Impaired cerebral autoregulation (CA) is common and associated with brain damage in sick neonates. Frequency analysis using spontaneous changes in arterial blood pressure (ABP) and cerebral near-infrared spectroscopy (NIRS) has been used to measure CA in several clinical studies. Coherence of the NIRS and ABP signals (i.e. correlation in the frequency-domain) detects impairment of CA, whereas gain (i.e. magnitude of ABP-variability passing from systemic to cerebral circulation) estimates the degree of this impairment. So far, however, this method has not been validated. In twelve newborn piglets, we compared NIRS-derived measures of CA with a conventional measure of CA: cerebral blood flow was measured by laser Doppler flowmetry and changes in ABP were induced by inflating a thoracic aorta balloon. CA-capacity was calculated as %ΔCVR/%ΔABP (i.e. percentage of full autoregulatory capacity), where CVR (i.e. cerebral vascular resistance) was estimated as ABP/Doppler flux. Correlation between coherence and CA-capacity (r=-0.34, n=24, p>0.05) as well as between gain and CA-capacity (r=-0.11, n=24, p>0.05) was limited. As expected, however, gain was significantly associated with CA-capacity in measurements with significant coherence (r=-0.55, n=15, p=0.03). In conclusion, our data validate frequency analysis for estimation of cerebral autoregulation in clinical research. Low precision, however, hampers its clinical application. ABBREVIATIONS:: |
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Authors:
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Gitte H Hahn; Christian Heiring; Ole Pryds; Gorm Greisen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-11 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neonatology [G.H.H., G.G.], Copenhagen University Hospital - Rigshospitalet, DK-2100 Copenhagen, Denmark; Department of Pediatrics [C.H.], Hillerød Hospital, DK-3400 Hillerød, Denmark; Department of Pediatrics [O.P.], Copenhagen University Hospital - Hvidovre Hospital, DK-2650 Hvidovre, Denmark. |
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