Document Detail


Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats.
MedLine Citation:
PMID:  12771330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the effect of apple components on cecal fermentations and lipid metabolism, rats were fed diets containing 5 g/100 g apple pectin (PEC), 10 g/100 g high polyphenol freeze-dried apple (PL) or both (PEC + PL). The cecal pH was slightly acidic (6.49) only in rats fed the PEC + PL diet (controls, 7.02). The cecal short-chain fatty acid pool was enlarged by all the apple fractions, with a peak of 560 micromol in rats fed the PEC + PL diet compared with 189 micromol in controls. Butyrate concentrations were 2-fold greater in rats fed the PL diet than in controls. Substantial concentrations of galacturonate and succinate (approximately 40 mmol/L) were found in the cecum of rats fed the PEC diet and, to a lesser extent, the PEC + PL diet. The PEC + PL diet significantly lowered plasma cholesterol, whereas both the PL and PEC + PL diets lowered plasma triglycerides. Liver cholesterol and triglyceride concentrations were lower in rats fed the PEC and PEC + PL diets. Fecal bile acid excretion was markedly reduced, whereas sterol excretion was significantly increased by dietary PEC. Rats fed the PEC and PEC + PL diets also had lower apparent cholesterol absorption than controls (30 compared with 43%). In conclusion, apple pectin and the polyphenol-rich fraction were more effective when fed combined together than when fed separately on large intestine fermentations and lipid metabolism, suggesting interactions between fibers and polyphenols of apple.
Authors:
Olivier Aprikian; Virgile Duclos; Sylvain Guyot; Catherine Besson; Claudine Manach; Annick Bernalier; Christine Morand; Christian Rémésy; Christian Demigné
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1860-5     Citation Subset:  IM    
Affiliation:
Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix, 63122 St-Genes-Champanelle, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anions / metabolism
Body Weight / drug effects
Cecum / metabolism*
Drug Combinations
Fatty Acids, Volatile / metabolism
Fermentation / drug effects*
Flavonoids*
Lipid Metabolism
Lipids / blood*
Male
Malus / chemistry*
Organ Size / drug effects
Pectins / pharmacology*
Phenols / pharmacology*
Polymers / pharmacology*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Anions; 0/Drug Combinations; 0/Fatty Acids, Volatile; 0/Flavonoids; 0/Lipids; 0/Pectins; 0/Phenols; 0/Polymers; 0/polyphenols; 9000-69-5/pectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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