| Appetitive hormones, but not isoflavone tablets, influence overall and central adiposity in healthy postmenopausal women. | |
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MedLine Citation:
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PMID: 20142790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: One of the multiple health benefits of soy protein or its isoflavones may be their purported favorable effect on body composition. We examined the effect of isoflavones extracted from soy protein on overall and regional body composition, taking into account appetitive hormones as potential mediators, as well as the direct effect on appetitive hormones. METHODS: This randomized, double-blind, placebo-controlled multicenter trial included 229 healthy postmenopausal women (age, 45.8-65 y; body mass index, 24.9 +/- 3.0 kg/m) who consumed placebo or soy isoflavone (80 or 120 mg/d) tablets for 12 months. We used intent-to-treat analysis to examine changes in body composition (whole-body lean mass, whole-body fat mass, androidal fat mass, and androidal-to-gynoidal fat mass ratio) and appetitive hormones (insulin, leptin, ghrelin, and adiponectin) in response to treatment. RESULTS: Repeated-measures analysis of variance indicated that soy isoflavone treatment did not exert a significant effect on body composition measures (P value from 0.36 to 0.79) or appetitive hormone concentrations; the inclusion of covariates in statistical models did not alter these results. Independently of treatment, leptin and ghrelin related inversely to each body composition measure (P values from 0.044 to < or = 0.0001). Adiponectin related inversely to all fat measures (P values from 0.0004 to <0.0001). Time since last menstrual period related directly to all fat measures (P values from 0.06 to 0.0055). Dietary fat contributed to whole-body (P = 0.028) and androidal (P = 0.017) fat mass. CONCLUSIONS: Our findings do not support a favorable effect of soy isoflavone tablets on body composition in healthy postmenopausal women. |
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Authors:
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Oksana A Matvienko; D Lee Alekel; Ulrike Genschel; Laura Ritland; Marta D Van Loan; Kenneth J Koehler |
Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 17 ISSN: 1530-0374 ISO Abbreviation: Menopause Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-08-06 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 594-601 Citation Subset: IM |
Affiliation:
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School of Health, Physical Education, and Leisure Services, University of Northern Iowa, Cedar Falls, IA 50614-0241, USA. : oksana.matvienko@uni.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00043745 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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metabolism Adipose Tissue / drug effects Adult Body Weight / drug effects* Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Female Ghrelin / metabolism Health Status Humans Insulin / metabolism Isoflavones / administration & dosage*, pharmacology Leptin / metabolism Middle Aged Peptide Hormones / metabolism* Postmenopause / drug effects, metabolism* Reference Values Soybean Proteins / administration & dosage*, pharmacology Women's Health |
| Grant Support | |
ID/Acronym/Agency:
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1M01RR19975-01/RR/NCRR NIH HHS; 95P50AT004155/AT/NCCAM NIH HHS; P01 ES012020/ES/NIEHS NIH HHS; R01 AR046922/AR/NIAMS NIH HHS; R01 AR046922-01A2/AR/NIAMS NIH HHS; UL1 RR024146/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Ghrelin; 0/Isoflavones; 0/Leptin; 0/Peptide Hormones; 0/Soybean Proteins; 11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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