Document Detail

Appetite-regulating hormones from the upper gut: disrupted control of xenin and ghrelin in night workers.
MedLine Citation:
PMID:  23199168     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Shift work is associated to circadian rhythm disorder, impaired sleep and behavioral changes, including eating habits, predisposing to obesity and metabolic dysfunctions. It involves a neuro-hormonal dysregulation of appetite towards positive energy balance, including increased ghrelin and decreased leptin, but little is known about other hormones, such as xenin, derived from the upper gut (like ghrelin), and lower gut hormones. Our objective was to compare night workers to day workers in relation to appetite-regulating hormones and other metabolic parameters. DESIGN: Cross-sectional, observational study. PARTICIPANTS: Twenty-four overweight women, divided in night shift workers (n=12) and day shift workers (n=12). MEASUREMENTS: BMI, waist circumference, fat mass percentage; diet composition; Pittsburgh Sleep Quality Index (PSQI); lipids; adipokines; meal tolerance test (MTT) curves of glucose, insulin, ghrelin, PYY3-36, oxyntomodulin, xenin, GLP-1; insulin sensitivity (Stumvoll index). RESULTS: Night workers, as compared to day workers, had greater body fat mass percentage and tendency to greater waist circumference despite of similar BMI; greater energy intake; impaired sleep; lower insulin sensitivity; increased triglycerides and tendency to increased C-reactive protein; similar levels of leptin and other adipokines. Night workers had a blunted post-meal suppression of ghrelin (AUCi(0-60min) 19.4±139.9 vs -141.9±9.0 ng/ml• 60min, p<0.01); blunted rise of xenin (AUC(0-180min) 8,690.9±2,988.2 vs 28,504.4±20,308.3 pg/ml•180min, p<0.01) and similar curves of PYY3-36, oxyntomodulin and GPL-1. CONCLUSION: Compared to day workers within the same BMI range, night workers presented a disrupted control of ghrelin and xenin, associated to behavioral changes in diet and sleep and increased adiposity and related metabolic alterations. © 2012 Blackwell Publishing Ltd.
Daniela Schiavo-Cardozo; Marcelo M O Lima; José Carlos Pareja; Bruno Geloneze
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-1
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Laboratory of Investigation in Metabolism and Diabetes (LIMED)/Gastrocentro, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
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