Document Detail

Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome.
MedLine Citation:
PMID:  22270375     Owner:  NLM     Status:  Publisher    
Objective:Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder with several nutritional phases during childhood proceeding from poor feeding, through normal eating without and with obesity, to hyperphagia and life-threatening obesity, with variable ages of onset. We investigated whether differences in appetite hormones may explain the development of abnormal eating behaviour in young children with PWS.Subjects:In this cross-sectional study, children with PWS (n=42) and controls (n=9) aged 7 months-5 years were recruited. Mothers were interviewed regarding eating behaviour, and body mass index (BMI) was calculated. Fasting plasma samples were assayed for insulin, leptin, glucose, peptide YY (PYY), ghrelin and pancreatic polypeptide (PP).Results:There was no significant relationship between eating behaviour in PWS subjects and the levels of any hormones or insulin resistance, independent of age. Fasting plasma leptin levels were significantly higher (mean±s.d.: 22.6±12.5 vs 1.97±0.79 ng ml(-1), P=0.005), and PP levels were significantly lower (22.6±12.5 vs 69.8±43.8 pmol l(-1), P<0.001) in the PWS group compared with the controls, and this was independent of age, BMI, insulin resistance or IGF-1 levels. However, there was no significant difference in plasma insulin, insulin resistance or ghrelin levels between groups, though PYY declined more rapidly with age but not BMI in PWS subjects.Conclusion:Even under the age of 5 years, PWS is associated with low levels of anorexigenic PP, as in older children and adults. Hyperghrelinaemia or hypoinsulinaemia was not seen in these young children with PWS. Change in these appetite hormones was not associated with the timing of the transition to the characteristic hyperphagic phase. However, abnormal and/or delayed development or sensitivity of the effector pathways of these appetitive hormones (for example, parasympathetic and central nervous system) may interact with low PP levels, and later hyperghrelinaemia or hypoinsulinaemia, to contribute to hyperphagia in PWS.International Journal of Obesity advance online publication, 24 January 2012; doi:10.1038/ijo.2011.274.
A P Goldstone; A J Holland; J V Butler; J E Whittington
Related Documents :
21538195 - Wool characteristics in the third generation of arkharmerino × ghezel and arkharmerino...
7484625 - Normal mr appearance of the pituitary gland in the first 2 years of life.
8042415 - Age-related changes in the size of thyrocyte nuclei in aspirates from nontoxic nodular ...
9269905 - Findings of computerized nuclear morphometry of papillary thyroid carcinoma in correlat...
20735645 - Secondary sexual characters and sperm traits in coho salmon oncorhynchus kisutch.
15567625 - The estimation of stature on the basis of measurements of the femur.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-24
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  -     ISSN:  1476-5497     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Approach to lipid therapy in the patient with atherosclerotic vascular disease.
Next Document:  The nicotinic acetylcholine receptor ?7 in subcutaneous mature adipocytes: downregulation in human o...