| Appendix cancer mimicking ovarian cancer. | |
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MedLine Citation:
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PMID: 12445258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Appendiceal adenocarcinoma is a rare malignancy for which there is no characteristic clinical presentation. We describe five women who presented with signs and symptoms characteristic of advanced ovarian cancer but whose final diagnosis was stage IV appendiceal cancer. Between 1998 and 1999, five women treated for presumed ovarian cancer were identified as having primary appendiceal cancer. Medical records and pathology were retrospectively reviewed. The median age was 47 years (range 36-61 years). All had elevated preoperative CA125 levels with a median value of 171 micro/ml (range 46-383). Four women underwent right hemicolectomy with two requiring radical surgical tumor debulking to render them optimally debulked. Four had postoperative chemotherapy, the most common agent used was 5-flourouracil. Median survival was 6.75 months (range 19 days-11 months). Primary adenocarcinoma of the appendix is rare; therefore, the clinical utility of radical tumor debulking and chemotherapy is not well described. Given the poor survival in our series, all efforts should be considered palliative. Although this disease process is uncommon, it should be entertained by gynecologic oncologists in the differential diagnosis of an intra-abdominal mass and ascites. The ability to make the correct diagnosis and differentiate between an ovarian and appendiceal primary is critical as the treatment modalities vary. |
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Authors:
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P A Gehrig; J F Boggess; D W Ollila; P A Groben; L Van Le |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 12 ISSN: 1048-891X ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2003-03-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 768-72 Citation Subset: IM |
Affiliation:
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Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. pam68@med.unc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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blood,
diagnosis,
drug therapy,
mortality*,
radiography,
secondary,
surgery Adult Appendiceal Neoplasms / blood, diagnosis, drug therapy, mortality*, pathology, radiography, surgery CA-125 Antigen / blood Chemotherapy, Adjuvant Diagnosis, Differential Female Humans Immunohistochemistry Keratins Medical Records Middle Aged North Carolina / epidemiology Ovarian Neoplasms / blood, diagnosis, drug therapy, mortality*, radiography, secondary, surgery Palliative Care Retrospective Studies Survival Analysis Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/CA-125 Antigen; 68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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