Document Detail

Appearance of abnormal electrocorticogram patterns during umbilical cord compression in sheep fetus.
MedLine Citation:
PMID:  16340168     Owner:  NLM     Status:  MEDLINE    
A frequent cause of fetal acidemia, which sometimes results in hypoxic-ischemic encephalopathy, is umbilical cord compression associated with uterine contraction. Using a sheep model of fetal acidemia, we examined the changes in electrocorticogram (ECoG), carotid artery blood flow, arterial blood pressure and fetal heart rate during cord compression. A characteristic burst of ECoG spikes emerged during cord compression at fetal arterial pH 7.18 even before the pH went down to severe fetal acidemia (less than 7.10). The administration of a neuromuscular blocking agent to the fetus did not abolish the appearance of the spikes. These results suggest that cord compression may cause abnormal brain excitement even in the absence of severe fetal acidemia and that this abnormal excitement can lead to fetal brain dysfunction, if cord compression is repeated or prolonged.
Takeshi Takahashi; Junichi Sugawara; Hiroshi Chisaka; Noriaki Imai; Masatoshi Saito; Takashi Murakami; Yoshitaka Kimura; Kunihiro Okamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  208     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-01-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  9-17     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
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MeSH Terms
Acidosis / metabolism*
Blood Gas Analysis
Blood Pressure / physiology
Fetal Hypoxia
Fetus / physiology*
Heart Rate, Fetal / physiology
Statistics as Topic
Umbilical Cord / pathology*

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