Document Detail


Apparent stimulation of thrombopoesis with interleukin-3 (IL-3) in chemotherapy induced myelosuppression.
MedLine Citation:
PMID:  8722119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two patients with advanced ovarian cancer (FIGO III C) and one patient with abdominal cancer developed severe thrombocytopenia with petechial haemorrhages after chemotherapy. These patients were treated with recombinant human interleukin-3 (rhIL-3) after multiple platelet transfusions (HLA-matched) and erythrocyte transfusions had not been effective. Increase of thrombocyte counts began three days after rhIL-3 therapy. Side effects due to rhIL-3 administration (flu-like symptoms) were moderate and could be treated effectively with paracetamol. These data support evidence for efficacy of rhIL-3 in chemotherapy-induced thrombocytopenia and may open new therapeutic perspectives.
Authors:
C Schweiger; L Färber; G Füchsel; D Heinrich; W Meinerz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  5     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:    1995-1996
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2006-07-19    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  73-4     Citation Subset:  IM    
Affiliation:
Sandoz AG, Clinical Research, Abt. KFO, Nuremberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Neoplasms / complications,  drug therapy*
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Bone Marrow / drug effects*
Female
Humans
Interleukin-3 / adverse effects*
Ovarian Neoplasms / complications,  drug therapy*
Stimulation, Chemical
Thrombocytopenia / chemically induced*
Chemical
Reg. No./Substance:
0/Interleukin-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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