Document Detail

Apparent role of dynein in glucose-6-phosphate dehydrogenase trafficking in neutrophils from pregnant women.
MedLine Citation:
PMID:  16483869     Owner:  NLM     Status:  MEDLINE    
To better understand the mechanisms of metabolic microcompartmentalization associated with neutrophil hexose monophosphate shunt activity during pregnancy, we have studied the intracellular trafficking of glucose-6-phosphate dehydrogenase (G6PDase). Microtubule motor proteins colocalize with G6PDase. Dynein inhibitors block G6PDase accumulation at the microtubule-organizing center in pregnancy cells. On this basis, we conclude that microtubule motor proteins participate in hexose monophosphate shunt enzyme transport within leukocytes.
Ji-Biao Huang; Jimmy Espinoza; Roberto Romero; Howard R Petty
Related Documents :
11704099 - Search for new chemical entities as menses inducing agents.
6430089 - The interactions of exercise and pregnancy: a review.
2210919 - Thymidine and somatomedin-like activity of fetal pig sera: effect of fetal decapitation.
2323049 - Measurement of pepsinogen group i in endoscopic gastroduodenal biopsies.
14652639 - Circulating levels of inflammatory cytokines (il-1 beta and tnf-alpha), resistance to a...
7570709 - Molecular identification of steroid analogs with dissociated antiprogestin activities.
19532039 - Managing antiepileptic drugs during pregnancy and lactation.
6186269 - Value of schwangerschaftsprotein 1 (sp1) and pregnancy-associated plasma protein-a (pap...
8264019 - Predicting pregnancy survival from a single first trimester vaginal ultrasonogram.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  55     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-17     Completed Date:  2006-06-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-81     Citation Subset:  IM    
Department of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, MI 48105, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Compartmentation
Dyneins / physiology*
Glucosephosphate Dehydrogenase / metabolism*
Microtubule Proteins / metabolism
Molecular Motor Proteins / metabolism
Neutrophils / chemistry,  metabolism*
Pentose Phosphate Pathway
Pregnancy / metabolism*
Protein Transport
Reg. No./Substance:
0/Microtubule Proteins; 0/Molecular Motor Proteins; EC Dehydrogenase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Caveolins and the regulation of endothelial nitric oxide synthase in the heart.
Next Document:  The effects of amino acid supplementation on hormonal responses to resistance training overreaching.