Document Detail


Apparent role of dynein in glucose-6-phosphate dehydrogenase trafficking in neutrophils from pregnant women.
MedLine Citation:
PMID:  16483869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To better understand the mechanisms of metabolic microcompartmentalization associated with neutrophil hexose monophosphate shunt activity during pregnancy, we have studied the intracellular trafficking of glucose-6-phosphate dehydrogenase (G6PDase). Microtubule motor proteins colocalize with G6PDase. Dynein inhibitors block G6PDase accumulation at the microtubule-organizing center in pregnancy cells. On this basis, we conclude that microtubule motor proteins participate in hexose monophosphate shunt enzyme transport within leukocytes.
Authors:
Ji-Biao Huang; Jimmy Espinoza; Roberto Romero; Howard R Petty
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  55     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-17     Completed Date:  2006-06-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-81     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, MI 48105, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Compartmentation
Dyneins / physiology*
Female
Glucosephosphate Dehydrogenase / metabolism*
Humans
Microtubule Proteins / metabolism
Molecular Motor Proteins / metabolism
Neutrophils / chemistry,  metabolism*
Pentose Phosphate Pathway
Pregnancy / metabolism*
Protein Transport
Chemical
Reg. No./Substance:
0/Microtubule Proteins; 0/Molecular Motor Proteins; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 3.6.4.2/Dyneins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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