Document Detail

Apparent retardation of aging in Drosophila melanogaster by inhibitors of reverse transcriptase.
MedLine Citation:
PMID:  7518199     Owner:  NLM     Status:  MEDLINE    
It is proposed that aging is induced by somatic replication of transposable elements (TEs). Most transposable elements in Drosophila reproduce by reverse transcription. Therefore inhibitors of reverse transcriptase were tested for their ability to retard aging in Drosophila melanogaster. Two inhibitors, phosphonoformic acid (PFA) and dideoxyinosine (ddI), were capable of prolonging life span when administered for the first half of the adult life. PFA was investigated further. It also produced a reduction in the rate of decline of behavior. PFA appeared not to act on an infectious agent in these experiments, nor did it alter the food intake. Analogues unable to inhibit RT had no life span prolonging effect at similar concentrations to that of PFA.
C J Driver; D J Vogrig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  717     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-08-08     Completed Date:  1994-08-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-97     Citation Subset:  IM    
Deakin University, Clayton, Vic., Australia.
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MeSH Terms
Aging / drug effects*
DNA Transposable Elements
Dideoxyadenosine / pharmacology*
Diphosphates / pharmacology
Drosophila melanogaster
Feeding Behavior / drug effects
Foscarnet / pharmacology*
Life Expectancy
Oxalates / pharmacology
Reverse Transcriptase Inhibitors*
Reg. No./Substance:
0/DNA Transposable Elements; 0/Diphosphates; 0/Oxalates; 0/Reverse Transcriptase Inhibitors; 4097-22-7/Dideoxyadenosine; 4428-95-9/Foscarnet; 7722-88-5/sodium pyrophosphate

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