Document Detail

Apparent prevention of neural tube defects by periconceptional vitamin supplementation.
MedLine Citation:
PMID:  7332338     Owner:  NLM     Status:  MEDLINE    
An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of per conceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1 (0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed.
R W Smithells; S Sheppard; C J Schorah; M J Seller; N C Nevin; R Harris; A P Read; D W Fielding
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  56     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2012-03-16    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  911-8     Citation Subset:  AIM; IM    
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MeSH Terms
Follow-Up Studies
Infant, Newborn
Maternal Age
Neural Tube Defects / epidemiology,  prevention & control*
Prenatal Care*
Social Class
Vitamins / therapeutic use*
Reg. No./Substance:

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