| Apparent prevention of neural tube defects by periconceptional vitamin supplementation*. | |
MedLine Citation:
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PMID: 22039189 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of periconceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1(0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed. |
Authors:
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Rw Smithells; S Sheppard; Cj Schorah; Mj Seller; Nc Nevin; R Harris; Ap Read; Dw Fielding |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of epidemiology Volume: 40 ISSN: 1464-3685 ISO Abbreviation: Int J Epidemiol Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802871 Medline TA: Int J Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 1146-54 Citation Subset: IM |
Affiliation:
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Department of Paediatrics and Child Health, University of Leeds; Paediatric Research Unit, Guy's Hospital, London; Department of Medical Genetics, Queen's University of Belfast; Department of Medical Genetics, University of Manchester; Department of Paediatrics, Chester. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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