Document Detail

Apparent prevention of neural tube defects by periconceptional vitamin supplementation*.
MedLine Citation:
PMID:  22039189     Owner:  NLM     Status:  In-Data-Review    
An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of periconceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1(0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed.
Rw Smithells; S Sheppard; Cj Schorah; Mj Seller; Nc Nevin; R Harris; Ap Read; Dw Fielding
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of epidemiology     Volume:  40     ISSN:  1464-3685     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1146-54     Citation Subset:  IM    
Department of Paediatrics and Child Health, University of Leeds; Paediatric Research Unit, Guy's Hospital, London; Department of Medical Genetics, Queen's University of Belfast; Department of Medical Genetics, University of Manchester; Department of Paediatrics, Chester.
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