| Apparent motion photometry: evaluation and reliability of a novel method for the measurement of macular pigment. | |
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MedLine Citation:
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PMID: 20805121 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background/aims Macular pigment is thought to protect the macula against exposure to light and oxidative stress, both of which may play a role in the development of age-related macular degeneration. The aim was to clinically evaluate a novel cathode-ray-tube-based method for measurement of macular pigment optical density (MPOD) known as apparent motion photometry (AMP). Methods The authors took repeat readings of MPOD centrally (0°) and at 3° eccentricity for 76 healthy subjects (mean (±SD) 26.5±13.2 years, range 18-74 years). Results The overall mean MPOD for the cohort was 0.50±0.24 at 0°, and 0.28±0.20 at 3° eccentricity; these values were significantly different (t=-8.905, p<0.001). The coefficients of repeatability were 0.60 and 0.48 for the 0 and 3° measurements respectively. Conclusions The data suggest that when the same operator is taking repeated 0° AMP MPOD readings over time, only changes of more than 0.60 units can be classed as clinically significant. In other words, AMP is not suitable for monitoring changes in MPOD over time, as increases of this magnitude would not be expected, even in response to dietary modification or nutritional supplementation. |
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Authors:
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Hannah Bartlett; Frank Eperjesi |
Publication Detail:
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Type: Journal Article Date: 2010-08-30 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 95 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 662-5 Citation Subset: IM |
Affiliation:
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Ophthalmic Research Group, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK; h.e.bartlett@aston.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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