| Apparent diffusion coefficient measurements of the pancreas, pancreas carcinoma and mass-forming focal pancreatitis. | |
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MedLine Citation:
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PMID: 22262868 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BackgroundMass-forming focal pancreatitis (FP) may mimic pancreatic cancer (PC) on magnetic resonance (MR) imaging, and the preoperative differential diagnosis is often difficult. Recently, the usefulness of diffusion-weighted imaging (DWI) in the diagnosis of pancreatic cancer has been reported in several studies.PurposeTo investigate if apparent diffusion coefficient (ADC) measurements based on diffusion-weighted echo-planar imaging (DW-EPI) may distinguish between normal pancreas parenchyma, mass-forming focal pancreatitis, and pancreas carcinoma.Material and MethodsMRI was performed on 64 patients: 24 with pancreas carcinoma (PC), 20 with mass-forming focal pancreatitis (FP), three patients with other focal pancreatic disease as well as 17 controls without any known pancreatic disease. Diffusion-weighted sequence with ADC maps and T2-weighted sequence for anatomical information was performed. Apparent diffusion coefficient (ADC) maps were automatically created and analyzed using a dedicated user interface. In the group with pancreas disease the abnormal parenchyma was detected by using T1- and T2-weighted images and the region of interest (ROI) was transferred exactly to the ADC map and the coefficients were registered. In the control group the ROI was set to the head of the pancreas followed by a similar registration of the ADCs.ResultsADC values for mass-forming FP and PC differed significantly from ADC values for normal pancreas parenchyma (P = 0.001/P = 0.002). Mean ADC values for mass-forming FP were 0.69 ± 0.18 × 10(-3) mm(2)/s. ADC values for PC were 0.78 ± 0.11 × 10(-3) mm(2)/s, compared to ADC values of 0.17 ± 0.06 × 10(-3) mm(2)/s in the control group. However there was no significant difference in ADCs between PC and mass-forming FP (P = 0.15).ConclusionADC measurements clearly differentiated between normal pancreatic tissue and abnormal pancreas parenchyma (PC and mass-forming FP). However there is an overlap in values of PC and mass-forming FP, with the consequent problem of their correct identification. |
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Authors:
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Philipp Wiggermann; Robert Grützmann; Angelika Weissenböck; Peter Kamusella; Dag-Daniel Dittert; Christian Stroszczynski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: - ISSN: 1600-0455 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University Medical Center Regensburg, Institute of Diagnostic Radiology, Regensburg. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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