| Apoptotic and proliferative activities in first trimester placentae. | |
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MedLine Citation:
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PMID: 10195745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apoptosis and cell proliferation are widely recognized to be important physiological processes which together maintain tissue homeostasis. The apoptotic and proliferative processes in 38 first trimester placentae were quantified using terminal deoxynucleotidyl transferase mediated dUTP nick end-labelling (TUNEL) and an antibody against Ki-67 antigen, respectively. In 14 cases, the estimation of apoptotic index was repeated with sections stained with haematoxylin and eosin by identifying the morphological features of apoptosis. We found that the indices obtained by either method correlated well with each other although a lower rate was obtained with the haematoxylin and eosin stained sections. Apoptosis was found in clusters mainly in syncytiotrophoblasts in association with fibrinoid deposits while proliferating activity was limited to cytotrophoblasts and stromal cells. A significant inverse correlation was observed between the proliferative index and gestational age as well as the apoptotic index. While the extent of apoptosis decreased with advanced gestational age, the correlation was not statistically significant. These findings provide a potential explanation for villous remodelling during trophoblastic invasion in early pregnancy. |
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Authors:
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C C Chan; T T Lao; A N Cheung |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Placenta Volume: 20 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 1999 Mar-Apr |
Date Detail:
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Created Date: 1999-05-27 Completed Date: 1999-05-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 223-7 Citation Subset: IM |
Affiliation:
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Department of Obstetrics & Gynaecology, University of Hong Kong, Queen Mary Hospital, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis* Cell Division* Female Gestational Age* Humans In Situ Nick-End Labeling Ki-67 Antigen / analysis Placenta / cytology* Pregnancy Pregnancy Trimester, First Trophoblasts / cytology, immunology |
| Chemical | |
Reg. No./Substance:
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0/Ki-67 Antigen |
| Comments/Corrections | |
Comment In:
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Placenta. 2000 Mar-Apr;21(2-3):286-8
[PMID:
10736256
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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