Document Detail

Apoptotic and proliferative activities in first trimester placentae.
MedLine Citation:
PMID:  10195745     Owner:  NLM     Status:  MEDLINE    
Apoptosis and cell proliferation are widely recognized to be important physiological processes which together maintain tissue homeostasis. The apoptotic and proliferative processes in 38 first trimester placentae were quantified using terminal deoxynucleotidyl transferase mediated dUTP nick end-labelling (TUNEL) and an antibody against Ki-67 antigen, respectively. In 14 cases, the estimation of apoptotic index was repeated with sections stained with haematoxylin and eosin by identifying the morphological features of apoptosis. We found that the indices obtained by either method correlated well with each other although a lower rate was obtained with the haematoxylin and eosin stained sections. Apoptosis was found in clusters mainly in syncytiotrophoblasts in association with fibrinoid deposits while proliferating activity was limited to cytotrophoblasts and stromal cells. A significant inverse correlation was observed between the proliferative index and gestational age as well as the apoptotic index. While the extent of apoptosis decreased with advanced gestational age, the correlation was not statistically significant. These findings provide a potential explanation for villous remodelling during trophoblastic invasion in early pregnancy.
C C Chan; T T Lao; A N Cheung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  20     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-05-27     Completed Date:  1999-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Department of Obstetrics & Gynaecology, University of Hong Kong, Queen Mary Hospital, China.
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MeSH Terms
Cell Division*
Gestational Age*
In Situ Nick-End Labeling
Ki-67 Antigen / analysis
Placenta / cytology*
Pregnancy Trimester, First
Trophoblasts / cytology,  immunology
Reg. No./Substance:
0/Ki-67 Antigen
Comment In:
Placenta. 2000 Mar-Apr;21(2-3):286-8   [PMID:  10736256 ]

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