| Apoptotic and non-apoptotic modes of programmed cell death in MCF-7 human breast carcinoma cells. | |
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MedLine Citation:
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PMID: 10816327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apoptosis is a specific mode of programmed cell death (PCD), recognized by characteristic morphological and molecular changes. Here we present evidence for a non-apoptotic type of PCD in human MCF-7 breast carcinoma cells. We used TNF-alpha and tyrphostin AG213 to induce apoptotic and non-apoptotic cell death respectively in vitro. Microscopic and immunohistochemical studies, together with DNA analysis and flow cytometric analysis of p53 and bcl-2 oncogene expression, revealed some novel characteristics of non-apoptotic cell death. We show here for the first time some of the biochemical features of an experimentally induced non-apoptotic PCD and emphasize the distinct biochemical events leading to apoptotic and non-apoptotic PCD. |
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Authors:
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F Amin; I D Bowen; Z Szegedi; R Mihalik; B Szende |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biology international Volume: 24 ISSN: 1065-6995 ISO Abbreviation: Cell Biol. Int. Publication Date: 2000 |
Date Detail:
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Created Date: 2000-06-13 Completed Date: 2000-06-13 Revised Date: 2008-09-04 |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 253-60 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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School of Biosciences, Cardiff University, Cardiff, CF1 3TL, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis* Breast Neoplasms / metabolism, pathology* Cell Nucleus / ultrastructure Comet Assay Cytoplasm / ultrastructure DNA Fragmentation DNA, Neoplasm / analysis Female Humans Microscopy, Electron, Scanning Microvilli / ultrastructure Proto-Oncogene Proteins c-bcl-2 / biosynthesis Pseudopodia / ultrastructure RNA, Neoplasm / analysis Tumor Cells, Cultured Tumor Necrosis Factor-alpha / pharmacology Tumor Suppressor Protein p53 / biosynthesis Tyrphostins / pharmacology Vacuoles / ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Proto-Oncogene Proteins c-bcl-2; 0/RNA, Neoplasm; 0/Tumor Necrosis Factor-alpha; 0/Tumor Suppressor Protein p53; 0/Tyrphostins; 118409-60-2/tyrphostin 47 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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