| Apoptotic events induced by human rhinovirus infection. | |
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MedLine Citation:
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PMID: 15831950 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HeLa and 16HBE14o(-) bronchial epithelium cells infected with human rhinovirus serotype 14 (HRV14) were found to exhibit typical apoptotic morphological alterations, such as cell contraction and nuclear condensation. These events coincided with high-molecular-weight DNA fragmentation, activation of caspase-9 and caspase-3 and poly(ADP-ribose) polymerase cleavage. Caspase activation was preceded by cytochrome c translocation from the mitochondria to the cytoplasm, indicating that apoptosis caused by HRV14 infection was triggered predominantly via the mitochondrial pathway. Apoptosis did not affect HRV14 replication per se, but it facilitated the release of newly formed virus from cells. As apoptosis was fully induced at the time of maximal accumulation of progeny HRV14, it is postulated that apoptosis contributed to the destabilization of the cell and facilitated viral progeny release. |
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Authors:
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Luiza Deszcz; Elisabeth Gaudernak; Ernst Kuechler; Joachim Seipelt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of general virology Volume: 86 ISSN: 0022-1317 ISO Abbreviation: J. Gen. Virol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-15 Completed Date: 2005-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: England |
Other Details:
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Languages: eng Pagination: 1379-89 Citation Subset: IM |
Affiliation:
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Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, Dr Bohr Gasse 9/3, A-1030 Vienna, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis* Caspase 3 Caspase 9 Caspases / analysis Cell Nucleus / pathology Cells, Cultured Cytochromes c / analysis Cytoplasm / chemistry DNA Fragmentation Epithelial Cells / cytology, physiology, virology* Humans Poly(ADP-ribose) Polymerases / analysis Rhinovirus / growth & development* |
| Chemical | |
Reg. No./Substance:
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9007-43-6/Cytochromes c; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/CASP9 protein, human; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases |
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