Document Detail


Apoptotic effect of CKD-602 (Camtobell) on oral squamous cell carcinoma cell lines.
MedLine Citation:
PMID:  18715816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purposes of this study were to measure the cytotoxic effect of CKD-602 on oral squamous cell carcinoma (OSCC) cell lines, to evaluate the apoptotic aspect of dead cells, and to identify the signaling molecules involved in apoptosis. The human OSCC cell lines A253, HSC-3 and KB were treated with CKD-602. The apoptotic proportion of the cells was analyzed using flow cytometry. The expression of Bax, Bcl-2, and p53 were detected by western blotting analysis. CKD-602 showed excellent cytotoxicity to the OSCC cell lines. Most cell death was attributed to apoptosis rather than necrosis. CKD-602 induced the down-regulation of Bcl-2 in A253 and HSC-3 cells, and p53 was expressed in the KB cell line after treatment with CKD-602.
Authors:
Yong-Ju Ok; Hoon Myoung; Young-Kyun Kim; Jong-Ho Lee; Myung-Jin Kim; Pil-Young Yun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-19
Journal Detail:
Title:  Oral oncology     Volume:  45     ISSN:  1879-0593     ISO Abbreviation:  Oral Oncol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-23     Completed Date:  2010-02-09     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  266-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects*
Camptothecin / analogs & derivatives*,  pharmacology
Carcinoma, Squamous Cell / drug therapy*,  genetics,  metabolism
Cell Line, Tumor
Humans
Mouth Mucosa
Mouth Neoplasms / drug therapy*,  genetics,  metabolism
Peptide Fragments
Proto-Oncogene Proteins c-bcl-2 / metabolism
Submandibular Gland Neoplasms / drug therapy,  genetics,  metabolism
Tongue Neoplasms / drug therapy,  genetics,  metabolism
Topoisomerase I Inhibitors*
Tumor Suppressor Protein p53 / biosynthesis
bcl-2-Associated X Protein / metabolism
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Peptide Fragments; 0/Proto-Oncogene Proteins c-bcl-2; 0/Topoisomerase I Inhibitors; 0/Tumor Suppressor Protein p53; 0/bcl-2-Associated X Protein; 0/p53 protein (325-355), human; 27Z82M2G1N/belotecan; XT3Z54Z28A/Camptothecin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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