Document Detail


Apoptotic cells at the crossroads of tolerance and immunity.
MedLine Citation:
PMID:  15791960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell, the nature of the receptors involved in apoptotic cell capture, and the milieu in which phagocytosis of apoptotic cells takes place. Preferential ligation of specific receptors on professional antigen-presenting cells (dendritic cells) has been proposed to induce potentially tolerogenic signals. On the other hand, dendritic cells can efficiently process and present antigens from pathogen-infected apoptotic cells to T cells. In this review, we discuss how apoptotic cells manipulate immunity through interactions with dendritic cells.
Authors:
M Skoberne; A S Beignon; M Larsson; N Bhardwaj
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current topics in microbiology and immunology     Volume:  289     ISSN:  0070-217X     ISO Abbreviation:  Curr. Top. Microbiol. Immunol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-28     Completed Date:  2005-04-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0110513     Medline TA:  Curr Top Microbiol Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  259-92     Citation Subset:  IM    
Affiliation:
Cancer Institute, NYU School of Medicine, 550 First Avenue, MSB507, New York, NY 10016, USA. mojca.skoberne@med.nyu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / immunology*
Dendritic Cells / cytology,  immunology*
Humans
Immune Tolerance / immunology*
Phagocytosis / immunology*
Receptors, Complement / immunology
T-Lymphocytes / immunology
Grant Support
ID/Acronym/Agency:
R01-AL061684//PHS HHS; R01-AL44628//PHS HHS; R21-AL55274//PHS HHS
Chemical
Reg. No./Substance:
0/Receptors, Complement

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