Document Detail


Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA.
MedLine Citation:
PMID:  12406559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated a set of cell lines as to their sensitivity to proliferation inhibition, on the one side, and apoptosis induction, on the other, by the core histone deacetylase inhibitors butyrate and trichostatin A (TSA), respectively. The results can be summarized as follows: (i) the investigated cell lines can be classified into three groups of high, medium and low sensitivity to proliferation inhibition by the histone deacetylase inhibitors; (ii) there is no correlation between the sensitivities to proliferation inhibition and the sensitivities to apoptosis induction by the histone deacetylase inhibitors; (iii) a comparison of the relative sensitivities to butyrate versus TSA with regard to proliferation inhibition and apoptosis induction, respectively, revealed that besides a good correlation most often encountered, there are also cell lines with conspicuously differing relative sensitivities to the two structurally different histone deacetylase inhibitors.
Authors:
Péter Gálfi; Zsuzsa Neogrády; Adam Csordás
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  188     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-01-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  141-52     Citation Subset:  IM    
Affiliation:
Faculty of Veterinary Medicine, Institute of Physiology and Biochemistry, Szent-István University, Budapest, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / drug effects*
Butyrates / pharmacology*
Cell Division / drug effects*
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Enzyme Inhibitors / pharmacology*
Gastrointestinal Neoplasms / enzymology,  pathology*
Histone Deacetylase Inhibitors*
Humans
Hydroxamic Acids / pharmacology*
Tumor Cells, Cultured / drug effects,  enzymology,  pathology
Chemical
Reg. No./Substance:
0/Butyrates; 0/Enzyme Inhibitors; 0/Histone Deacetylase Inhibitors; 0/Hydroxamic Acids; 58880-19-6/trichostatin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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