| Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA. | |
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MedLine Citation:
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PMID: 12406559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated a set of cell lines as to their sensitivity to proliferation inhibition, on the one side, and apoptosis induction, on the other, by the core histone deacetylase inhibitors butyrate and trichostatin A (TSA), respectively. The results can be summarized as follows: (i) the investigated cell lines can be classified into three groups of high, medium and low sensitivity to proliferation inhibition by the histone deacetylase inhibitors; (ii) there is no correlation between the sensitivities to proliferation inhibition and the sensitivities to apoptosis induction by the histone deacetylase inhibitors; (iii) a comparison of the relative sensitivities to butyrate versus TSA with regard to proliferation inhibition and apoptosis induction, respectively, revealed that besides a good correlation most often encountered, there are also cell lines with conspicuously differing relative sensitivities to the two structurally different histone deacetylase inhibitors. |
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Authors:
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Péter Gálfi; Zsuzsa Neogrády; Adam Csordás |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 188 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-10-30 Completed Date: 2003-01-13 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 141-52 Citation Subset: IM |
Affiliation:
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Faculty of Veterinary Medicine, Institute of Physiology and Biochemistry, Szent-István University, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects* Butyrates / pharmacology* Cell Division / drug effects* Dose-Response Relationship, Drug Drug Resistance, Neoplasm Enzyme Inhibitors / pharmacology* Gastrointestinal Neoplasms / enzymology, pathology* Histone Deacetylase Inhibitors* Humans Hydroxamic Acids / pharmacology* Tumor Cells, Cultured / drug effects, enzymology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Butyrates; 0/Enzyme Inhibitors; 0/Histone Deacetylase Inhibitors; 0/Hydroxamic Acids; 58880-19-6/trichostatin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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