Document Detail

Apoptosis sensitivity is not correlated with sensitivity to proliferation inhibition by the histone deacetylase inhibitors butyrate and TSA.
MedLine Citation:
PMID:  12406559     Owner:  NLM     Status:  MEDLINE    
We investigated a set of cell lines as to their sensitivity to proliferation inhibition, on the one side, and apoptosis induction, on the other, by the core histone deacetylase inhibitors butyrate and trichostatin A (TSA), respectively. The results can be summarized as follows: (i) the investigated cell lines can be classified into three groups of high, medium and low sensitivity to proliferation inhibition by the histone deacetylase inhibitors; (ii) there is no correlation between the sensitivities to proliferation inhibition and the sensitivities to apoptosis induction by the histone deacetylase inhibitors; (iii) a comparison of the relative sensitivities to butyrate versus TSA with regard to proliferation inhibition and apoptosis induction, respectively, revealed that besides a good correlation most often encountered, there are also cell lines with conspicuously differing relative sensitivities to the two structurally different histone deacetylase inhibitors.
Péter Gálfi; Zsuzsa Neogrády; Adam Csordás
Related Documents :
7496399 - The distribution of a spliceosome protein in cereal (triticeae) interphase nuclei from ...
15248029 - Synergistic killing of human leukemia cells by antioxidants and trichostatin a.
16537359 - Automated local bright feature image analysis of nuclear protein distribution identifie...
17951399 - Histone deacetylase inhibitors: overview and perspectives.
16212499 - Pushing the envelope: structure, function, and dynamics of the nuclear periphery.
25304369 - The src homology 3 binding domain is required for lysophosphatidic acid 3 receptor-medi...
3300529 - Killing of saccharomyces cerevisiae by the lysosomotropic detergent n-dodecylimidazole.
21783659 - Ex vivo cancer chemoprevention research possibilities.
11359999 - The in vitro inhibitory effect of tannin derivatives on 3-hydroxy-3-methylglutaryl-coen...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  188     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-01-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  141-52     Citation Subset:  IM    
Faculty of Veterinary Medicine, Institute of Physiology and Biochemistry, Szent-István University, Budapest, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apoptosis / drug effects*
Butyrates / pharmacology*
Cell Division / drug effects*
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Enzyme Inhibitors / pharmacology*
Gastrointestinal Neoplasms / enzymology,  pathology*
Histone Deacetylase Inhibitors*
Hydroxamic Acids / pharmacology*
Tumor Cells, Cultured / drug effects,  enzymology,  pathology
Reg. No./Substance:
0/Butyrates; 0/Enzyme Inhibitors; 0/Histone Deacetylase Inhibitors; 0/Hydroxamic Acids; 58880-19-6/trichostatin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messeng...
Next Document:  Unsaturated fatty acids bind Myc-Max transcription factor and inhibit Myc-Max-DNA complex formation.