Document Detail


Apoptosis-related factors p53, bcl-2 and the defects of force transmission in dilated cardiomyopathy.
MedLine Citation:
PMID:  20591580     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The etiology of heart failure in dilated cardiomyopathy involves multiple agents. The purpose of this study was to investigate the presence of apoptosis-related proteins p53, bcl-2, and the defects of force transmission in end-stage dilated cardiomyopathy. We studied myocardial samples from 20 hearts with histologic findings of dilated cardiomyopathy. Myocardial samples obtained from 10 normal hearts were used as controls. An immunohistochemical method was performed with the use of desmin, N-cadherin, p53, and bcl-2 antibodies. The expression of desmin and N-cadherin was much more pronounced in dilated cardiomyopathy, and both of them were arranged disorderly. On the other hand, increased expression of p53 is associated with progressive loss of myocytes by apoptosis in heart failure, and increased expression of bcl-2 represents a possible compensatory antiapoptotic mechanism. The increased amount and the irregular distribution of desmin and N-cadherin in dilated cardiomyopathy may compensate for the loss of cellular stability due to the loss of contractile material. These alterations contribute to the deterioration of contractile function in heart failure. Furthermore, the prevalence of an apoptotic or compensatory antiapoptotic mechanism may influence the evolution of heart failure in dilated cardiomyopathy.
Authors:
Angelos Tsipis; Anna Maria Athanassiadou; Pauline Athanassiadou; Nikolaos Kavantzas; George Agrogiannis; Efstratios Patsouris
Publication Detail:
Type:  Journal Article     Date:  2010-06-29
Journal Detail:
Title:  Pathology, research and practice     Volume:  206     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  625-30     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier GmbH. All rights reserved.
Affiliation:
1st Department of Pathology, Medical School, University of Athens, Chalandri, TK 15234 Athens, Greece. angelosathens@netscape.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Apoptosis / physiology*
Cadherins / biosynthesis
Cardiomyopathy, Dilated / complications,  metabolism*,  pathology*
Cytoskeleton / metabolism,  pathology*
Desmin / biosynthesis
Female
Heart Failure / etiology,  metabolism
Humans
Immunohistochemistry
Male
Middle Aged
Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
Tumor Suppressor Protein p53 / biosynthesis*
Chemical
Reg. No./Substance:
0/Cadherins; 0/Desmin; 0/Proto-Oncogene Proteins c-bcl-2; 0/TP53 protein, human; 0/Tumor Suppressor Protein p53

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