Document Detail

Apoptosis occurs in lymphoma cells but not in hepatoma cells following ionizing radiation and photodynamic therapy.
MedLine Citation:
PMID:  7956617     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine the relative role of apoptosis in photodynamically-induced cytotoxicity or radiation-induced cytotoxicity for hepatoma and lymphoma cells. Human hepatoma cells and mouse lymphoma cells were treated with either photodynamic therapy (PDT) or ionizing radiation. Dosimetry studies of immediate cell death following photodynamic therapy in the hepatoma cell line demonstrated second-order kinetics, similar to that seen in the lymphoma cells. No immediate cell death was noted in the hepatoma or lymphoma cells following ionizing radiation, but experiments measuring delayed cell death demonstrated a dose-dependent response. Maximum DNA ladder formation occurred 2 hr after PDT and 24 hr after ionizing radiation in the lymphoma cells, which was consistent with the time courses of cell death for these treatments. The hepatoma cell line did not demonstrate DNA ladder formation despite dosages of PDT or ionizing radiation sufficient to cause high levels of cytotoxicity.
M A Laukka; K K Wang; J A Bonner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  39     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-13     Completed Date:  1994-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2467-75     Citation Subset:  AIM; IM    
Division of Gastroenterology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905.
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MeSH Terms
Hematoporphyrin Derivative / pharmacology
Liver Neoplasms, Experimental / drug therapy*,  physiopathology,  radiotherapy*
Lymphoma / drug therapy*,  physiopathology,  radiotherapy*
Tumor Cells, Cultured / drug effects,  radiation effects
Reg. No./Substance:
68335-15-9/Hematoporphyrin Derivative

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