| Apoptosis occurs in lymphoma cells but not in hepatoma cells following ionizing radiation and photodynamic therapy. | |
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MedLine Citation:
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PMID: 7956617 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine the relative role of apoptosis in photodynamically-induced cytotoxicity or radiation-induced cytotoxicity for hepatoma and lymphoma cells. Human hepatoma cells and mouse lymphoma cells were treated with either photodynamic therapy (PDT) or ionizing radiation. Dosimetry studies of immediate cell death following photodynamic therapy in the hepatoma cell line demonstrated second-order kinetics, similar to that seen in the lymphoma cells. No immediate cell death was noted in the hepatoma or lymphoma cells following ionizing radiation, but experiments measuring delayed cell death demonstrated a dose-dependent response. Maximum DNA ladder formation occurred 2 hr after PDT and 24 hr after ionizing radiation in the lymphoma cells, which was consistent with the time courses of cell death for these treatments. The hepatoma cell line did not demonstrate DNA ladder formation despite dosages of PDT or ionizing radiation sufficient to cause high levels of cytotoxicity. |
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Authors:
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M A Laukka; K K Wang; J A Bonner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 39 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-13 Completed Date: 1994-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2467-75 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology and Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Hematoporphyrin Derivative / pharmacology Liver Neoplasms, Experimental / drug therapy*, physiopathology, radiotherapy* Lymphoma / drug therapy*, physiopathology, radiotherapy* Mice Photochemotherapy* Tumor Cells, Cultured / drug effects, radiation effects |
| Chemical | |
Reg. No./Substance:
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68335-15-9/Hematoporphyrin Derivative |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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