| Apoptosis is involved in the senescence of endothelial cells induced by angiotensin II. | |
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MedLine Citation:
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PMID: 17959395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular endothelial cells have a finite cell lifespan and eventually enter an irreversible growth arrest, cellular senescence. The functional changes associated with cellular senescence are thought to contribute to human aging and age-related cardiovascular disorders, e.g. atherosclerosis. In this study, induction of Angiotensin II (Ang II) promoted a growth arrest with phenotypic characteristics of cell senescence, such as enlarged cell shapes, increased senescence-associated beta-galactosidase (SA-beta-gal) positive staining cell, and depressed cell proliferation. Apoptotic changes were increased in senescent cells, with a small subset of the senescent cells showing aberrant morphology such as pronounced nuclear fragmentation or multiple micronuclei. The results suggest cell apoptosis is possibly an important factor in the process of pathologic and physiologic senescence of endothelial cells as well as vascular aging. |
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Authors:
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Hai-Yan Shan; Xiao-Juan Bai; Xiang-Mei Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-19 |
Journal Detail:
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Title: Cell biology international Volume: 32 ISSN: 1065-6995 ISO Abbreviation: Cell Biol. Int. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-29 Completed Date: 2008-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
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Languages: eng Pagination: 264-70 Citation Subset: IM |
Affiliation:
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Department of Cardiology, The First Affiliated Hospital of China Medical University, No.155, Nanjing North street, Heping District, Shenyang, Liaoning Province 110001, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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metabolism* Apoptosis / physiology* Biological Markers / metabolism Cell Aging / physiology* Cell Cycle / physiology Cell Line Cell Shape Cell Survival Endothelial Cells / physiology*, ultrastructure Humans Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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