Document Detail


Apoptosis induction of Centella asiatica on human breast cancer cells.
MedLine Citation:
PMID:  20162036     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The present study evaluated the ability of methanolic extract of Centella asiatica (Linn) Urban (Umbelliferae) to induce apoptosis in different cancer cell lines. MCF-7 cells emerged as the most sensitive cell line for in vitro growth inhibitory activity. C. asiatica extract induced apoptosis in MCF-7 cells as indicated by nuclear condensation, increased annexin staining, loss of mitochondrial membrane potential and induction of DNA breaks identified by TUNEL reactivity. It is possible that the use of C. asiatica extract as a component in herbal medicines could be justifiable.
Authors:
Suboj Babykutty; Jose Padikkala; Priya Prasanna Sathiadevan; Vinod Vijayakurup; Thasni Karedath Abdul Azis; Priya Srinivas; Srinivas Gopala
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Publication Detail:
Type:  Journal Article     Date:  2008-10-25
Journal Detail:
Title:  African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines     Volume:  6     ISSN:  0189-6016     ISO Abbreviation:  Afr J Tradit Complement Altern Med     Publication Date:  2008  
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-05-20     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101232990     Medline TA:  Afr J Tradit Complement Altern Med     Country:  Nigeria    
Other Details:
Languages:  eng     Pagination:  9-16     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Sree Chitra Tirunal Institute for Medial Sciences and Technology, Thiruvananthapuram 695011, Kerala, India.
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