| Apoptosis induction of Centella asiatica on human breast cancer cells. | |
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MedLine Citation:
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PMID: 20162036 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The present study evaluated the ability of methanolic extract of Centella asiatica (Linn) Urban (Umbelliferae) to induce apoptosis in different cancer cell lines. MCF-7 cells emerged as the most sensitive cell line for in vitro growth inhibitory activity. C. asiatica extract induced apoptosis in MCF-7 cells as indicated by nuclear condensation, increased annexin staining, loss of mitochondrial membrane potential and induction of DNA breaks identified by TUNEL reactivity. It is possible that the use of C. asiatica extract as a component in herbal medicines could be justifiable. |
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Authors:
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Suboj Babykutty; Jose Padikkala; Priya Prasanna Sathiadevan; Vinod Vijayakurup; Thasni Karedath Abdul Azis; Priya Srinivas; Srinivas Gopala |
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Publication Detail:
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Type: Journal Article Date: 2008-10-25 |
Journal Detail:
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Title: African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines Volume: 6 ISSN: 0189-6016 ISO Abbreviation: Afr J Tradit Complement Altern Med Publication Date: 2008 |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-20 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 101232990 Medline TA: Afr J Tradit Complement Altern Med Country: Nigeria |
Other Details:
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Languages: eng Pagination: 9-16 Citation Subset: - |
Affiliation:
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Department of Biochemistry, Sree Chitra Tirunal Institute for Medial Sciences and Technology, Thiruvananthapuram 695011, Kerala, India. |
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