| Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells. | |
| | |
MedLine Citation:
|
PMID: 16517139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We evaluated the antitumor activity of tocotrienol (T3) on human hepatoma Hep3B cells. At first, we examined the effect of T3 on the proliferation of human hepatoma Hep3B cells and found that gamma-T3 inhibited cell proliferation at lower concentrations and shorter treatment times than alpha-T3. Then, we examined the effect of gamma-T3 apoptosis induction and found that gamma-T3 induced poly (ADP-ribose) polymerase (PARP) cleavage and stimulated a rise in caspase-3 activity. In addition, gamma-T3 stimulated a rise in caspase-8 and caspase-9 activities. We also found that gamma-T3-induced apoptotic cell death was accompanied by up-regulation of Bax and a rise in the fragments of Bid and caspase-8. These data indicate that gamma-T3 induced apoptosis in Hep3B cells and that caspase-8 and caspase-9 were involved in apoptosis induction. Moreover, these results suggest that Bax and Bid regulated apoptosis induction by gamma-T3. |
| | |
Authors:
|
Midori Sakai; Masaaki Okabe; Hirofumi Tachibana; Koji Yamada |
Related Documents
:
|
19029949 - Calpain small-1 modulates akt/foxo3a signaling and apoptosis through pp2a. 12420309 - Catecholamine-induced oligodendrocyte cell death in culture is developmentally regulate... 20032379 - Apoptotic signalling in hela hep2 cells following 5 gy of cobalt-60 gamma radiation. 17881119 - Protein expression and intracellular localization of prostate apoptosis response-4 (par... 9707099 - Effects of poly(adp-ribose) polymerase inhibition on cell death and chromosome damage i... 12114629 - Mediation of poly(adp-ribose) polymerase-1-dependent cell death by apoptosis-inducing f... 9454729 - Nerve growth factor and ceramides modulate cell death in the early developing inner ear. 20804439 - Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cance... 16777169 - Cxcr4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immatu... |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2005-11-28 |
Journal Detail:
|
Title: The Journal of nutritional biochemistry Volume: 17 ISSN: 0955-2863 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-09-22 Completed Date: 2006-11-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
|
Languages: eng Pagination: 672-6 Citation Subset: IM |
Affiliation:
|
Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apoptosis
/
drug effects* Carcinoma, Hepatocellular Caspase 3 Caspase 8 Caspase 9 Caspases / metabolism Cell Division / drug effects Cell Line, Tumor Chromans / pharmacology* Gene Expression / drug effects Genes, bcl-2 / drug effects Humans Liver Neoplasms Poly(ADP-ribose) Polymerases / metabolism Vitamin E / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Chromans; 1406-18-4/Vitamin E; 1721-51-3/tocotrienol, alpha; 25612-59-3/tocotrienol, delta; 4382-43-8/plastochromanol 8; EC 2.4.2.30/Poly(ADP-ribose) Polymerases; EC 3.4.22.-/CASP3 protein, human; EC 3.4.22.-/CASP8 protein, human; EC 3.4.22.-/CASP9 protein, human; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 8; EC 3.4.22.-/Caspase 9; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospi...
Next Document: Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells...