| Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder. | |
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MedLine Citation:
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PMID: 16186816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Removal of toxic substances from the blood depends on patent connections between the kidney, ureters and bladder that are established when the ureter is transposed from its original insertion site in the male genital tract to the bladder. This transposition is thought to occur as the trigone forms from the common nephric duct and incorporates into the bladder. Here we re-examine this model in the context of normal and abnormal development. We show that the common nephric duct does not differentiate into the trigone but instead undergoes apoptosis, a crucial step for ureter transposition controlled by vitamin A-induced signals from the primitive bladder. Ureter abnormalities occur in 1-2% of the human population and can cause obstruction and end-stage renal disease. These studies provide an explanation for ureter defects underlying some forms of obstruction in humans and redefine the current model of ureter maturation. |
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Authors:
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Ekatherina Batourina; Sheaumei Tsai; Sarah Lambert; Preston Sprenkle; Renata Viana; Sonia Dutta; Terry Hensle; Fengwei Wang; Karen Niederreither; Andrew P McMahon; Thomas J Carroll; Cathy L Mendelsohn |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. Date: 2005-09-25 |
Journal Detail:
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Title: Nature genetics Volume: 37 ISSN: 1061-4036 ISO Abbreviation: Nat. Genet. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-30 Completed Date: 2005-12-20 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9216904 Medline TA: Nat Genet Country: United States |
Other Details:
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Languages: eng Pagination: 1082-9 Citation Subset: IM |
Affiliation:
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Columbia University, Department of Urology, 650 West 168th Street, New York, New York 10032, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Homeodomain Proteins / genetics Mice Mice, Transgenic Nephrons / cytology, embryology* Organogenesis / genetics Signal Transduction Ureter / embryology* Urinary Bladder / embryology* Vitamin A / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK061459-01A1/DK/NIDDK NIH HHS; R01 DK061459-01A1S1/DK/NIDDK NIH HHS; R01 DK061459-02/DK/NIDDK NIH HHS; R01 DK061459-03/DK/NIDDK NIH HHS; R01 DK061459-04/DK/NIDDK NIH HHS; R01 DK061459-05/DK/NIDDK NIH HHS; R01 DK061459-06/DK/NIDDK NIH HHS; R01 DK061459-07/DK/NIDDK NIH HHS; R01 DK061459-07S1/DK/NIDDK NIH HHS; R01 DK061459-08/DK/NIDDK NIH HHS; R01 DK061459-09/DK/NIDDK NIH HHS; R56 DK082963-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/Hoxb7 protein, mouse; 11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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