Document Detail

Apoptosis induced by peste des petits ruminants virus in goat peripheral blood mononuclear cells.
MedLine Citation:
PMID:  11172915     Owner:  NLM     Status:  MEDLINE    
The ability of peste des petits ruminants virus (PPRV) to induce apoptosis in goat peripheral blood mononuclear cell (PBMC) culture was investigated. Goat PBMC were infected with PPRV and the infectivity was confirmed by cytopathic effect, demonstration of presence of infectious viral progeny and expression of viral antigens in the lymphocytes, cultured in vitro. Infected PBMC showed morphological features of apoptosis. DNA extracted from PPRV-infected cells displayed laddering pattern in agarose gel electrophoresis. Infected cells also showed significantly higher apoptotic indices measured by bisbenzimide staining than control cells. Electronmicrographs of PPRV-infected PBMC revealed features typical of apoptosis such as peripheral condensation of chromatin, blebbing of plasma membrane, fragmentation of nucleus and cell leading to formation of apoptotic bodies. Our results suggest that PPRV can induce apoptosis, in vitro, in goat lymphocytes.
B Mondal; B P Sreenivasa; P Dhar; R P Singh; S K Bandyopadhyay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virus research     Volume:  73     ISSN:  0168-1702     ISO Abbreviation:  Virus Res.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-08-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8410979     Medline TA:  Virus Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Division of Virology, Indian Veterinary Research Institute, UP 263138, Mukteswar, India.
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MeSH Terms
Cells, Cultured
Cytopathogenic Effect, Viral
Leukocytes, Mononuclear / pathology*,  virology
Peste-des-petits-ruminants virus / pathogenicity*

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