Document Detail


Apoptosis induced by peste des petits ruminants virus in goat peripheral blood mononuclear cells.
MedLine Citation:
PMID:  11172915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of peste des petits ruminants virus (PPRV) to induce apoptosis in goat peripheral blood mononuclear cell (PBMC) culture was investigated. Goat PBMC were infected with PPRV and the infectivity was confirmed by cytopathic effect, demonstration of presence of infectious viral progeny and expression of viral antigens in the lymphocytes, cultured in vitro. Infected PBMC showed morphological features of apoptosis. DNA extracted from PPRV-infected cells displayed laddering pattern in agarose gel electrophoresis. Infected cells also showed significantly higher apoptotic indices measured by bisbenzimide staining than control cells. Electronmicrographs of PPRV-infected PBMC revealed features typical of apoptosis such as peripheral condensation of chromatin, blebbing of plasma membrane, fragmentation of nucleus and cell leading to formation of apoptotic bodies. Our results suggest that PPRV can induce apoptosis, in vitro, in goat lymphocytes.
Authors:
B Mondal; B P Sreenivasa; P Dhar; R P Singh; S K Bandyopadhyay
Related Documents :
14528275 - Emerging roles of dna tumor viruses in cell proliferation: new insights into genomic in...
16651385 - A virus-encoded telomerase rna promotes malignant t cell lymphomagenesis.
21906325 - Erythropoietin (epo) in acute kidney injury.
17338855 - Pathogenesis of hiv in the gastrointestinal tract.
10680715 - Lipopolysaccharide-stimulated nitric oxide production and inhibition of cell proliferat...
19414755 - Activation of melanoma differentiation-associated gene 5 causes rapid involution of the...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virus research     Volume:  73     ISSN:  0168-1702     ISO Abbreviation:  Virus Res.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-08-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8410979     Medline TA:  Virus Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Affiliation:
Division of Virology, Indian Veterinary Research Institute, UP 263138, Mukteswar, India. bimalendu.m@mailcity.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Cells, Cultured
Cytopathogenic Effect, Viral
Goats
Leukocytes, Mononuclear / pathology*,  virology
Peste-des-petits-ruminants virus / pathogenicity*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of the genome-linked protein in virions of Potato virus A, with comparison to other m...
Next Document:  Differences in inhibition of replication between Coxsackie B4 virus strains in various cell lines by...