| Apoptosis induced by modified ribonucleosides in human cell culture systems. | |
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MedLine Citation:
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PMID: 9744808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The in vitro modulation of apoptosis and cell proliferation by modified in comparison with non-modified ribonucleosides was investigated for the first time using peripheral blood lymphocytes, HL-60 cells and Caco-2 cells as human cell culture models. Modulating effects of several ribonucleosides were found in the range of 10(-7)-10(-3) mol/l. The following ribonucleosides induced significant apoptosis of HL-60 cells: adenosine, N6-dimethyladenosine, N6-(2-isopentenyl)-adenosine, N2-dimethylguanosine. A significant apoptotic effect on PBL was found with N6-dimethyladenosine and N6-(2-isopentenyl)-adenosine. N6-Dimethyladenosine, N6-(2-isopentenyl)-adenosine and guanosine had a pronounced inhibitory effect on Caco-2 cell apoptosis. Regarding the known function of ribonucleosides as pathobiochemical marker molecules for cancer, the possibility of a selective apoptotic effect against malignant cells is discussed. |
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Authors:
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H Meisel; S Günther; D Martin; E Schlimme |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FEBS letters Volume: 433 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-10-08 Completed Date: 1998-10-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 265-8 Citation Subset: IM |
Affiliation:
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Bundesanstalt für Milchforschung, Institut für Chemie und Physik, Kiel, Germany. meisel@bafm.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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analogs & derivatives,
pharmacology Apoptosis / drug effects* Cells, Cultured Colonic Neoplasms Guanosine / analogs & derivatives, pharmacology HL-60 Cells / cytology, drug effects Humans Inosine / analogs & derivatives, pharmacology Isopentenyladenosine / pharmacology Kinetics Lymphocytes / cytology, drug effects*, physiology Ribonucleosides / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Ribonucleosides; 118-00-3/Guanosine; 58-61-7/Adenosine; 58-63-9/Inosine; 7724-76-7/Isopentenyladenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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