Document Detail

Apoptosis in psoriasis.
MedLine Citation:
PMID:  19818217     Owner:  NLM     Status:  MEDLINE    
Apoptosis is a process of programmed cell death that maintains homeostasis of the skin. Apoptotic cell death regulates keratinocyte proliferation and formation of stratum corneum. The process by which keratinocytes undergo apoptosis is a multistep program mediated by binding of specific death ligands to death receptors or by the release of effector cell granules. Dysfunctional apoptosis has an important role in the development of several skin diseases. Psoriasis is a common chronic inflammatory skin disease characterized by hyperproliferation with incomplete differentiation of epidermal keratinocytes and decreased keratinocyte apoptosis. Psoriatic keratinocytes possess an enhanced ability to resist apoptosis, which might be one of the key pathogenetic mechanisms in psoriasis. In addition, psoriasis is nowadays also recognized as the most prevalent autoimmune disease resulting from aberrant activation of both innate and adaptive immunity. However, the role of cell cytotoxicity mediated by cytotoxic CD8+ T cells and NK cells in psoriasis is as yet unclear. Here, we review the role of different apoptotic pathways in psoriasis.
Marija Kastelan; Larisa Prpić-Massari; Ines Brajac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta dermatovenerologica Croatica : ADC     Volume:  17     ISSN:  1330-027X     ISO Abbreviation:  Acta Dermatovenerol Croat     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-12     Completed Date:  2010-08-26     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  9433781     Medline TA:  Acta Dermatovenerol Croat     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  182-6     Citation Subset:  IM    
University Department of Dermatology and Venereology, Rijeka University Hospital Center and School of Medicine, Kresimirova 42, HR-51000 Rijeka, Croatia.
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MeSH Terms
Apoptosis / immunology*
Cytokines / immunology
Granzymes / immunology
Keratinocytes / immunology*
Killer Cells, Natural / immunology
Perforin / immunology
Proto-Oncogene Proteins c-bcl-2 / immunology,  physiology
Psoriasis / immunology*
T-Lymphocytes, Cytotoxic / immunology
Reg. No./Substance:
0/Cytokines; 0/Proto-Oncogene Proteins c-bcl-2; 126465-35-8/Perforin; EC 3.4.21.-/Granzymes

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