| Apoptosis in the peripheral blood mononuclear cells as a self-limitation process in human acute pancreatitis. | |
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MedLine Citation:
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PMID: 12138725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIM: Acute pancreatitis is primed and sustained by a chain of immuno-inflammatory factors. In this study, we investigated the possible existence of peripheral blood mononuclear cell apoptosis as a self-limitation mechanism in acute pancreatitis. METHODS: Peripheral blood mononuclear cell apoptosis was determined cytofluorometrically daily for 10 days from the onset of the illness in 27 consecutive patients (18 having mild uncomplicated acute pancreatitis and 9 having pancreatitis with complications) and was related to peripheral blood counts, including reticulocytes and reticulocyte fractions, and albumin, fibrinogen, and C-reactive protein levels. RESULTS: In the 18 patients with uncomplicated acute pancreatitis, the rate of peripheral blood apoptosis increased progressively until days 5-6 and then decreased. The 9 patients who developed complications showed levels of peripheral blood apoptosis stable across the five periods and lower than those with uncomplicated disease during the first four periods. This difference was statistically significant (p = 0.002) only on days 7-8. On days 9-10, the patients with complications showed higher levels of peripheral blood apoptosis than those with mild uncomplicated acute pancreatitis (p = 0.0005). Peripheral blood apoptosis was not significantly related to the other laboratory parameters, but there was a trend towards an inverse relation to reticulocytes and total leucocytes (p < 0.09). CONCLUSIONS: Peripheral blood apoptosis may act as a mechanism of self-limitation of the process of acute pancreatitis. Its effects, however, seem to be hampered and delayed by the presence of complications. |
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Authors:
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Teresa Salomone; Patrizia Tosi; Carlo Raiti; Aurelia Guariento; Paola Tomassetti; Marina Migliori; Calogero Saieva; Maurizio Romboli; Lucio Gullo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Volume: 2 ISSN: 1424-3903 ISO Abbreviation: Pancreatology Publication Date: 2002 |
Date Detail:
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Created Date: 2002-07-25 Completed Date: 2003-01-17 Revised Date: 2006-03-28 |
Medline Journal Info:
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Nlm Unique ID: 100966936 Medline TA: Pancreatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 204-10 Citation Subset: IM |
Affiliation:
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Emergency Department, S. Orsola Hospital, Bologna, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Aged, 80 and over Apoptosis / physiology* Disease Progression Erythrocyte Count Female Humans Leukocyte Count Male Middle Aged Monocytes / physiology* Pancreatitis / blood*, complications, physiopathology Reticulocytes / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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