| Apoptosis in patients with acute myocarditis. | |
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MedLine Citation:
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PMID: 19766770 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute myocarditis is an acute inflammatory syndrome characterized by acute myocardial damage and dysfunction followed by a variable recovery over time with some patients progressing toward severe dilated cardiomyopathy. Cardiomyocyte apoptosis, a key pathologic feature of heart failure, may play a critical role in functional recovery in patients with acute myocarditis. The aim of the study was to investigate whether apoptosis predicts functional recovery in patients with acute myocarditis. Sixteen patients with biopsy-documented acute myocarditis were followed for 1 year with serial transthoracic echocardiography. Functional recovery was defined as 12-month left ventricular ejection fraction >40%. Cardiomyocyte apoptosis, leukocyte infiltration, and cell proliferation was assessed in all samples. A group of cases in which the diagnosis of acute myocarditis was made after death was also selected for comparison, and morphologically normal hearts from patients who died from a noncardiac cause were selected as controls. Six patients (38%) had functional recovery at 12 months, whereas 10 (62%) did not. The 2 groups had similar characteristics except for lower baseline left ventricular ejection fraction in the group with functional recovery. Apoptotic rate was found to be significantly higher in patients with acute myocarditis than in control hearts, and, unexpectedly, patients with functional recovery had significantly higher apoptotic rates than patients without recovery (3.2% vs 0.5%, p = 0.001). None of the patients with apoptotic rates below the median had functional recovery versus 86% of patients with apoptotic rates above the median (p <0.001). In conclusion, higher rates of cardiomyocyte apoptosis in patients with acute myocarditis are associated with functional recovery at 1 year. |
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Authors:
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Antonio Abbate; Gianfranco Sinagra; Rossana Bussani; Nicholas N Hoke; Marco Merlo; Amit Varma; Stefano Toldo; Fadi N Salloum; Giuseppe G L Biondi-Zoccai; George W Vetrovec; Filippo Crea; Furio Silvestri; Alfonso Baldi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 104 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-21 Completed Date: 2009-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 995-1000 Citation Subset: AIM; IM |
Affiliation:
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VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA. aabbate@mcvh-vcu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Apoptosis* Biological Markers / analysis Biopsy, Needle Echocardiography Female Humans Immunohistochemistry In Situ Nick-End Labeling Male Middle Aged Myocardial Contraction / physiology Myocarditis / mortality, pathology*, physiopathology, ultrasonography* Myocytes, Cardiac / pathology* Probability Prospective Studies Recovery of Function Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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