Document Detail


Apoptosis in male germ cells in response to cyclin A1-deficiency and cell cycle arrest.
MedLine Citation:
PMID:  14555236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Male mice homozygous for a mutated allele of the cyclin A1 gene (Ccna1) are sterile due to a block in cell cycle progression before the first meiotic division. Meiosis arrest in Ccna1(-/-) spermatocytes is associated with desynapsis abnormalities, lowered MPF activity, and apoptosis as evidenced by TUNEL-positive staining. With time, adult testicular tubules exhibit severe degeneration: some tubules in the older animals are almost devoid of germ cells at various stages of spermatogenesis. The mechanisms by which the cells sense the cell cycle arrest and the regulation of the decision to undergo cell death are under investigation.
Authors:
Glicella Salazar; Dong Liu; Ching Liao; Leah Batkiewicz; Rachel Arbing; Sanny S W Chung; Karen Lele; Debra J Wolgemuth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  66     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-13     Completed Date:  2003-11-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1571-9     Citation Subset:  IM; S    
Affiliation:
Department of Genetics & Development, Institute of Human Nutrition, Center for Reproductive Sciences, College of Physicians & Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / physiology*
Cell Cycle / physiology
Cyclin A / deficiency*,  genetics,  metabolism
Cyclin A1
Germ Cells / pathology*
Male
Mice
Mutagenesis
Spermatogenesis / physiology
Grant Support
ID/Acronym/Agency:
HD34915/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Ccna1 protein, mouse; 0/Cyclin A; 0/Cyclin A1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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