Document Detail


Apoptosis of immune cells in the tumor microenvironment and peripheral circulation of patients with cancer: implications for immunotherapy.
MedLine Citation:
PMID:  12477428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rapid turnover of lymphocytes observed in patients with cancer appears to be driven by increased apoptosis of T lymphocytes or insufficient thymic output of recent thymic emigrants (RTE). Using multicolor flow cytometry and apoptosis assays, we found that CD8+CD95+Annexin+ T cells are dying at a rate that is significantly higher in patients with cancer than in normal controls (NC). CD8+ effector subsets of T cells were particularly vulnerable to apoptosis. Thymic excision circle (TREC) analysis of peripheral blood lymphocytes showed a decreased number of RTE in these patients. Together, the data suggest that a high rate of T-cell turnover might contribute to immunologic imbalance in patients with cancer and have unfavorable effects on immunotherapy, including therapeutic antitumor vaccines.
Authors:
Theresa L Whiteside
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vaccine     Volume:  20 Suppl 4     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-12     Completed Date:  2003-07-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  A46-51     Citation Subset:  IM    
Affiliation:
University of Pittsburgh Cancer Institute, 200 Lothrop Street, BST 211, W1041, Pittsburgh, PA 15213-2582, USA. whitesidet@msx.upmc.edu
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / immunology*
CD8-Positive T-Lymphocytes / immunology
Humans
Immunotherapy*
Neoplasms / immunology,  pathology*,  therapy

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