| Apoptosis of immune cells in the tumor microenvironment and peripheral circulation of patients with cancer: implications for immunotherapy. | |
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MedLine Citation:
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PMID: 12477428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rapid turnover of lymphocytes observed in patients with cancer appears to be driven by increased apoptosis of T lymphocytes or insufficient thymic output of recent thymic emigrants (RTE). Using multicolor flow cytometry and apoptosis assays, we found that CD8+CD95+Annexin+ T cells are dying at a rate that is significantly higher in patients with cancer than in normal controls (NC). CD8+ effector subsets of T cells were particularly vulnerable to apoptosis. Thymic excision circle (TREC) analysis of peripheral blood lymphocytes showed a decreased number of RTE in these patients. Together, the data suggest that a high rate of T-cell turnover might contribute to immunologic imbalance in patients with cancer and have unfavorable effects on immunotherapy, including therapeutic antitumor vaccines. |
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Authors:
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Theresa L Whiteside |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Vaccine Volume: 20 Suppl 4 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-12 Completed Date: 2003-07-14 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: Netherlands |
Other Details:
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Languages: eng Pagination: A46-51 Citation Subset: IM |
Affiliation:
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University of Pittsburgh Cancer Institute, 200 Lothrop Street, BST 211, W1041, Pittsburgh, PA 15213-2582, USA. whitesidet@msx.upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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immunology* CD8-Positive T-Lymphocytes / immunology Humans Immunotherapy* Neoplasms / immunology, pathology*, therapy |
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