Document Detail


Apoptosis imaging to monitor cancer therapy: The road to fast treatment evaluation?
MedLine Citation:
PMID:  22214506     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Molecular imaging of biological processes may allow detection of therapy effects before the tumor is reduced in size. The most frequently used PET tracer in oncology, 2-[18F]fluoro-2-deoxyglucose (FDG), suffers from low specificity due to uptake in inflammatory cells. The proliferation marker, 3'-[18F]fluoro-3'-deoxy-L-thymidine (FLT), is less influenced by the inflammatory response following therapy but here disease- and drug-specific effects need to be considered. Since cancer therapy mainly intends to eliminate cancer cells, imaging of cell death offers a direct way to image therapy response. This review gives an overview of the radiopharmaceutical development and in vivo evaluation of radioligands that have emerged so far for detection and assessment of apoptosis and necrosis. Two radiopharmaceuticals that can image cell death have made it to clinical trials for follow up of tumor treatment: i) 99mTc-and 123I-labelled AnxA5 for the response to treatment of for example lymphoma and lung cancer and ii) 18F-ML10 for the evaluation of brain tumors post-radiation. Other agents need further optimization.
Authors:
Marijke De Saint-Hubert; Matthias Bauwens; Alfons Verbruggen; Felix M Mottaghy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-2
Journal Detail:
Title:  Current pharmaceutical biotechnology     Volume:  -     ISSN:  1873-4316     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960530     Medline TA:  Curr Pharm Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Klinik für Nuklearmedizin, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, GERMANY. Email: fmottaghy@ukaachen.de.
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