Document Detail

Apoptosis identified by DNA fragmentation in epidermal neoplasms.
MedLine Citation:
PMID:  8647997     Owner:  NLM     Status:  MEDLINE    
In the previous study, we demonstrated apoptotic cells in basal cell carcinomas by means of terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL). Positive staining cells were present at the peripheries and centers of the nests. The number of positive cells increased in cases showing deep infiltration. We also stained other epidermal neoplasms using this modified TUNEL method. In squamous cell carcinomas, many positive cells were observed in poorly differentiated types, but only a few cells were stained in well-differentiated types. TUNEL positive cells were rare in Bowen's disease. No positive cells were seen in seborrheic keratosis or verruca vulgaris. Our studies showed that apoptotic cells were more common in rapid growth neoplasms than in slow growth neoplasms.
O Mori; H Hachisuka; C Kiyokawa; Y Sasai
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  22     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-07-22     Completed Date:  1996-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  917-20     Citation Subset:  IM    
Department of Dermatology, Kurume University School of Medicine, Japan.
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MeSH Terms
Bowen's Disease / pathology*
Carcinoma, Squamous Cell / pathology*
DNA Damage*
DNA Nucleotidylexotransferase
DNA, Neoplasm / analysis
Keratosis, Seborrheic / pathology
Skin Diseases / pathology
Skin Neoplasms / pathology*
Staining and Labeling / methods
Warts / pathology
Reg. No./Substance:
0/DNA, Neoplasm; EC Nucleotidylexotransferase

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