Document Detail


Apoptosis and heart failure: clinical relevance and therapeutic target.
MedLine Citation:
PMID:  15623423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure is the final common pathway of diverse etiologies that are characterized by impaired systolic and/or diastolic function with high morbidity and mortality. An integral part of pathogenesis of heart failure is myocyte loss. The traditional explanation for myocyte loss was cell necrosis but over the last decade, there has been a surge of evidence affirming the role of apoptosis in genesis of heart failure. Studies have raised apoptosis from a 'histologic curiosity' to an exciting 'clinical target' that can be modulated to attenuate the progression of heart failure. This review will focus on the clinical relevance of apoptosis in human and experimental heart failure and identify some of the progress made in myocardial anti-apoptotic intervention.
Authors:
Shaila Garg; Jagat Narula; Y Chandrashekhar
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Publication Detail:
Type:  Journal Article; Review     Date:  2004-12-13
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  38     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-29     Completed Date:  2005-05-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
Affiliation:
Drexel University College of Medicine, Philadelphia, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Cardiomyopathies / pathology*,  physiopathology,  therapy*
Disease Progression
Humans
Myocardial Reperfusion Injury / pathology,  therapy

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