| Apoptosis during retinoic acid-induced differentiation of F9 embryonal carcinoma cells. | |
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MedLine Citation:
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PMID: 7925658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this work we have characterized a process of cell death by apoptosis occurring in retinoic acid-induced differentiation of F9 embryonal carcinoma cells. Morphological changes corresponding to apoptosis were observed concomitantly with those of differentiated phenotype, in cell cultures treated for 48 h with physiological concentrations of all-trans-retinoic acid. Internucleosomal DNA fragmentation was also detected using agarose gels. These observations show that retinoic acid can induce both differentiation and apoptosis in an experimental system--the teratocarcinoma stem cell lines--widely used so far in the study of differentiation. We present this system as a tool for a better understanding of the role of retinoic acid in the regulation of cell differentiation and programmed cell death. |
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Authors:
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R Atencia; M García-Sanz; F Unda; J Aréchaga |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental cell research Volume: 214 ISSN: 0014-4827 ISO Abbreviation: Exp. Cell Res. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1994-11-04 Completed Date: 1994-11-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0373226 Medline TA: Exp Cell Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 663-7 Citation Subset: IM |
Affiliation:
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Departamento de Biología Celular, Facultad de Medicina, Universidad del País Vasco, Vizcaya, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology* Cell Differentiation DNA / analysis DNA Damage Flow Cytometry Mice Teratocarcinoma / pathology*, ultrastructure Tretinoin / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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302-79-4/Tretinoin; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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