| Apoptosis during CABG surgery with the use of cardiopulmonary bypass is prominent in ventricular but not in atrial myocardium. | |
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MedLine Citation:
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PMID: 20505796 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objectives. We aimed to compare the rate of apoptosis after cardiopulmonary bypass (CPB) and cardioplegic arrest during coronary artery bypass grafting (CABG) surgery between atrial and ventricular tissue.Methods. During CABG surgery with CPB and cardioplegic arrest, sequential biopsies were taken from the right atrial appendage and left ventricular anterior wall before CPB and after aortic cross clamp release. Change in number of apoptotic cells and biochemical markers of myocardial ischaemia and renal dysfunction were assessed.Results. CPB was associated with a transient small, but significant increase in CK (1091+/-374%), CK-MB (128+/-38%), troponin-T (102+/-13%) and NT-proBNP (1308+/-372%) levels (all: p<0.05). A higher number of apoptotic cells as assessed by caspase-3 staining was found in the ventricular biopsies taken after aortic cross clamp release compared with the biopsies taken before CPB (5.3+/-0.6 vs. 14.0+/-1.5 cells/microscopic field, p<0.01). The number of apoptotic cells in the atrial appendage was not altered during CPB. Correlation between the duration of aortic cross clamp time and the change in caspase-3 positive cells in the left ventricular wall was of borderline significance (r of 0.58, p=0.08). Similar results were obtained from TUNEL staining for apoptosis.Conclusion. CABG surgery with CPB and cardioplegic arrest is associated with an elevated rate of apoptosis in ventricular but not in atrial myocardial tissue. Ventricular tissue may be more sensitive to detect changes than atrial tissue, and may be more useful to investigate the protective effects of therapeutic intervention. (Neth Heart J 2010;18:236-42.). |
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Authors:
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W T Ruifrok; B D Westenbrink; R A de Boer; I J den Hamer; M E Erasmus; H E Mungroop; A H Epema; A A Voors; D J van Veldhuisen; W H van Gilst |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation Volume: 18 ISSN: 1568-5888 ISO Abbreviation: Neth Heart J Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101095458 Medline TA: Neth Heart J Country: Netherlands |
Other Details:
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Languages: eng Pagination: 236-42 Citation Subset: - |
Affiliation:
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Department of Cardiology, University Medical Center Groningen, Groningen, the Netherlands. |
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