Document Detail

Apoptosis, cell adhesion and the extracellular matrix in the three-dimensional growth of multicellular tumor spheroids.
MedLine Citation:
PMID:  11033298     Owner:  NLM     Status:  MEDLINE    
In the last few years, it has become increasingly apparent that cell survival and death, especially apoptosis, strongly depend on cell adhesion and the extracellular matrix. In addition, it has also become clear that the use of three-dimensional multicellular tumor spheroids, which mimick more closely solid tumors in vivo, are a realistic experimental model to investigate many aspects of tumor biology. In the present review, after a general overview of the current knowledge regarding apoptosis, cell adhesion and the extracellular matrix, the results obtained utilizing multicellular tumor spheroids in these types of studies are discussed. The main conclusion that may be drawn from a synthesis of the literature on these topics is that investigations with multicellular tumor spheroids yield much useful information that is sometimes in contradiction to that obtained with monolayer cultures, but is closer to that derived from in vivo studies. Consequently, the authors encourage that these three-dimensional systems be used in many studies in which cell death and adhesion are being examined.
M T Santini; G Rainaldi; P L Indovina
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in oncology/hematology     Volume:  36     ISSN:  1040-8428     ISO Abbreviation:  Crit. Rev. Oncol. Hematol.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-01-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8916049     Medline TA:  Crit Rev Oncol Hematol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  75-87     Citation Subset:  IM    
Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
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MeSH Terms
Cell Adhesion
Cell Communication*
Cell Culture Techniques / methods*
Extracellular Matrix / pathology*
Spheroids, Cellular / pathology*

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