Document Detail

Apoptosis and caspases.
MedLine Citation:
PMID:  11787807     Owner:  NLM     Status:  MEDLINE    
The expedition into the apoptosis signaling pathway, although it has just begun, has resulted in the discovery of a significant number of remarkable signaling molecules at all levels of this novel pathway After the pinnacle of this frenetic cloning effort has been reached, however, it is important to put this pathway and its constituents into a biological and pathophysiological context. It has become clear that cell death does not automatically mean activation of caspases. The recent discovery of a function of effector caspases of the apoptosis pathway outside of apoptosis is currently revolutionizing our view of these seemingly unrelated and rather counteracting processes, cell death and cell proliferation. It appears that caspases play a much more fundamental role in cells than originally expected.
A H Stegh; M E Peter
Related Documents :
18309327 - The molecular archaeology of a mitochondrial death effector: aif in drosophila.
18835037 - Combination of rituximab with blinatumomab (mt103/medi-538), a t cell-engaging cd19-/cd...
11811787 - Anti-p-glycoprotein antibody-induced apoptosis of activated peripheral blood lymphocyte...
11390657 - Molecular cloning of ilp-2, a novel member of the inhibitor of apoptosis protein family.
18755847 - Cellular players and role of selectin ligands in leukocyte recruitment in a t-cell-init...
15383577 - Relevance of the direct pathway of sensitization in corneal transplantation is dictated...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology clinics     Volume:  19     ISSN:  0733-8651     ISO Abbreviation:  Cardiol Clin     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2002-01-11     Completed Date:  2002-02-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8300331     Medline TA:  Cardiol Clin     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-29     Citation Subset:  IM    
The Ben May Institute for Cancer Research University of Chicago, Illinois 60637, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apoptosis / physiology*
Cardiovascular Diseases / physiopathology*
Caspases / physiology*
Reg. No./Substance:
EC 3.4.22.-/Caspases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Apoptosis in atherosclerosis. Does it contribute to plaque instability?
Next Document:  Apoptosis in cardiac transplant rejection.