Document Detail


Apoptosis as a scaffold for building up the B cell repertoire.
MedLine Citation:
PMID:  11193029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Control of cell number is determined by a balance between cell proliferation and cell death, both of which are highly regulated processes, with numerous checks and balances. Cells control their own death through activation of an internally coded suicide program that, when activated, initiates a characteristic form of cell death called apoptosis. This type of regulation allows elimination of cells that have been produced in excess, that have developed improperly, or that have sustained genetic damage. Apoptosis is, therefore, the most common physiological form of cell death and occurs during embryonic development, tissue remodeling, immune regulation, cell activation and tumor regression.
Authors:
A Brás; A Ruiz-Vela; D García-Domingo; C Martínez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  926     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-17     Completed Date:  2001-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-29     Citation Subset:  IM    
Affiliation:
Department of Immunology & Oncology, Centro Nacional de Biotecnología/CSIC, Universidad Autónoma, Campus de Cantoblanco, E-28049 Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
1-Phosphatidylinositol 3-Kinase / metabolism
Animals
Antigens, CD40 / metabolism
Antigens, CD95 / genetics,  metabolism
Apoptosis / physiology*
B-Lymphocytes / immunology,  physiology*
Cell Line
Interleukin-4 / metabolism
Receptors, Antigen, B-Cell / metabolism*
Signal Transduction*
Chemical
Reg. No./Substance:
0/Antigens, CD40; 0/Antigens, CD95; 0/Receptors, Antigen, B-Cell; 207137-56-2/Interleukin-4; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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