| Apoptosis as a scaffold for building up the B cell repertoire. | |
MedLine Citation:
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PMID: 11193029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Control of cell number is determined by a balance between cell proliferation and cell death, both of which are highly regulated processes, with numerous checks and balances. Cells control their own death through activation of an internally coded suicide program that, when activated, initiates a characteristic form of cell death called apoptosis. This type of regulation allows elimination of cells that have been produced in excess, that have developed improperly, or that have sustained genetic damage. Apoptosis is, therefore, the most common physiological form of cell death and occurs during embryonic development, tissue remodeling, immune regulation, cell activation and tumor regression. |
Authors:
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A Brás; A Ruiz-Vela; D García-Domingo; C Martínez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 926 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2000 |
Date Detail:
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Created Date: 2001-01-17 Completed Date: 2001-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 13-29 Citation Subset: IM |
Affiliation:
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Department of Immunology & Oncology, Centro Nacional de Biotecnología/CSIC, Universidad Autónoma, Campus de Cantoblanco, E-28049 Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism Animals Antigens, CD40 / metabolism Antigens, CD95 / genetics, metabolism Apoptosis / physiology* B-Lymphocytes / immunology, physiology* Cell Line Interleukin-4 / metabolism Receptors, Antigen, B-Cell / metabolism* Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD40; 0/Antigens, CD95; 0/Receptors, Antigen, B-Cell; 207137-56-2/Interleukin-4; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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