| Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. | |
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MedLine Citation:
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PMID: 8733377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening diseases characterized by extensive epidermal destruction. The aim of our study was to investigate apoptosis in keratinocytes of patients with TEN and TEN/SJS overlap syndrome. Keratinocytes from TEN patients were found to undergo extensive apoptosis. These results suggest that cell destruction in TEN occurs as a result of apoptosis. Our findings suggest that apoptosis inhibitory agents may play an important part in the therapeutic strategy of TEN. |
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Authors:
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C Paul; P Wolkenstein; H Adle; J Wechsler; H J Garchon; J Revuz; J C Roujeau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of dermatology Volume: 134 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-10-10 Completed Date: 1996-10-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 710-4 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Hôpital Henri Mondor, Créteil, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Apoptosis* / genetics DNA / genetics DNA Nucleotidylexotransferase / genetics Epidermal Necrolysis, Toxic / genetics, pathology* Humans Keratinocytes / ultrastructure* Middle Aged Nucleosomes / genetics Stevens-Johnson Syndrome / genetics, pathology |
| Chemical | |
Reg. No./Substance:
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0/Nucleosomes; 9007-49-2/DNA; EC 2.7.7.31/DNA Nucleotidylexotransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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