Document Detail

Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis.
MedLine Citation:
PMID:  8733377     Owner:  NLM     Status:  MEDLINE    
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are life-threatening diseases characterized by extensive epidermal destruction. The aim of our study was to investigate apoptosis in keratinocytes of patients with TEN and TEN/SJS overlap syndrome. Keratinocytes from TEN patients were found to undergo extensive apoptosis. These results suggest that cell destruction in TEN occurs as a result of apoptosis. Our findings suggest that apoptosis inhibitory agents may play an important part in the therapeutic strategy of TEN.
C Paul; P Wolkenstein; H Adle; J Wechsler; H J Garchon; J Revuz; J C Roujeau
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  134     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-10     Completed Date:  1996-10-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  710-4     Citation Subset:  IM    
Department of Dermatology, Hôpital Henri Mondor, Créteil, France.
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MeSH Terms
Aged, 80 and over
Apoptosis* / genetics
DNA / genetics
DNA Nucleotidylexotransferase / genetics
Epidermal Necrolysis, Toxic / genetics,  pathology*
Keratinocytes / ultrastructure*
Middle Aged
Nucleosomes / genetics
Stevens-Johnson Syndrome / genetics,  pathology
Reg. No./Substance:
0/Nucleosomes; 9007-49-2/DNA; EC Nucleotidylexotransferase

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