Document Detail


Apoptosis and antioxidant status are influenced by age and exercise training in horses.
MedLine Citation:
PMID:  18156356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight mature (12 +/- 2 yr; MAT) and 5 older (22 +/- 2 yr; OLD) Standardbred mares were used to test the hypothesis that aging and exercise training would alter apoptosis in white blood cells and antioxidant status. The horses were housed indoors overnight (16 h/d) in 3 m x 3 m stalls and were turned out in a drylot during the day. They were fed a diet consisting of total mixed ration, hay cubes fed ad libitum or an equine senior diet plus grass hay. Horses were trained for 20 to 30 min/d, 3 to 5 d/wk for 8 wk at a submaximal work intensity between 60 to 70% of maximal heart rate. A graded exercise test (GXT; stepwise test until exhaustion) was performed before (GXT1) and after (GXT2) the 8 wk of training. During the GXT, blood samples and heart rate were taken at rest, 6 m/s, fatigue, and at 5 and 60 min postfatigue. Fatigue plasma lactate concentration was greater in MAT (19.3 +/- 1.5 at 10 m/s) compared with the OLD (10.9 +/- 1.2 mmol/L at 9 m/s; P = 0.008) horses. There was no effect of age or training on plasma lipid hydroperoxide (LPO) concentration. However, there was a positive correlation between LPO and plasma lactate concentration (r = 0.27, P = 0.006) during acute exercise. There was a greater concentration of total glutathione after GXT1 than after GXT2 (111.8 +/- 5.0 vs. 98.6 +/- 3.4 microM, respectively; P = 0.0002) for both age groups. Apoptosis was less (P = 0.002) in white blood cells of the MAT vs. the OLD group. These results demonstrate that older horses are under similar amounts of oxidative stress, measured by LPO, and have similar levels of glutathione in their systems compared with mature horses. The observation that more glutathione was needed during GXT1 for both groups of horses indicates that training helps horses adapt their system for the intense post-training exercise tests. The greater level of white blood cell apoptosis also indicates that older horses may be immune-compromised during exercise. However, research still needs to be performed regarding dietary supplementation in the aged horse.
Authors:
C A Williams; M E Gordon; C L Betros; K H McKeever
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Publication Detail:
Type:  Journal Article     Date:  2007-12-21
Journal Detail:
Title:  Journal of animal science     Volume:  86     ISSN:  1525-3163     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  576-83     Citation Subset:  IM    
Affiliation:
Department of Animal Science, Equine Science Center, Rutgers, the State University of New Jersey, New Brunswick 08901, USA. cwilliams@aesop.rutgers.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animal Feed / analysis
Animals
Apoptosis / physiology*
Erythrocytes / chemistry
Female
Glutathione / blood
Glutathione Peroxidase / blood
Horses / physiology*
Lactic Acid / blood
Leukocytes / physiology
Lipid Peroxides / blood
Physical Conditioning, Animal / methods,  physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Lipid Peroxides; 50-21-5/Lactic Acid; 70-18-8/Glutathione; EC 1.11.1.9/Glutathione Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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