| Apoptosis, antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f. | |
| | |
MedLine Citation:
|
PMID: 22221758 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: To study the chemical constituents of stembark of Garcinia malaccensis (G. malaccensis) together with apoptotic, antimicrobial and antioxidant activities. METHODS: Purification and structure elucidation were carried out by chromatographic and spectroscopic techniques, respectively. MTT and trypan blue exclusion methods were performed to study the cytotoxic activity. Antibacterial activity was conducted by disc diffusion and microdilution methods, whereas antioxidant activities were done by ferric thiocyanate method and DPPH radical scavenging. RESULTS: The phytochemical study led to the isolation of α,β-mangostin and cycloart-24-en-3β-ol. α-Mangostin exhibited cytotoxic activity against HSC-3 cells with an IC(50) of 0.33 μM. β- and α-mangostin showed activity against K562 cells with IC(50) of 0.40 μM and 0.48 μM, respectively. α-Mangostin was active against Gram-positive bacteria, Staphylococcus aureus (S. aureus) and Bacilus anthracis (B. anthracis) with inhibition zone and MIC value of (19 mm; 0.025 mg/mL) and (20 mm; 0.013 mg/mL), respectively. In antioxidant assay, α-mangostin exhibited activity as an inhibitor of lipid peroxidation. CONCLUSIONS: G. malaccensis presence α- and β-mangostin and cycloart-24-en-3β-ol. β-Mangostin was found very active against HSC-3 cells and K562. The results suggest that mangostins derivatives have the potential to inhibit the growth of cancer cells by inducing apoptosis. In addition, α-and β-mangostin was found inhibit the growth of Gram-positive pathogenic bacteria and also showed the activity as an inhibitor of lipid peroxidation. |
| | |
Authors:
|
Muhammad Taher; Deny Susanti; Mohamad Fazlin Rezali; Farah Syahidah Ahmad Zohri; Solachuddin Jauhari Arief Ichwan; Suhaib Ibrahim Alkhamaiseh; Farediah Ahmad |
Related Documents
:
|
2013378 - Stimulation of pancreas and gastric carcinoma cell growth by interleukin 3 and granuloc... 22091928 - Ecology of borrelia burgdorferi sensu lato in europe: transmission dynamics in multi-ho... 17158648 - Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human ... 21111718 - Linking hypoxic and oxidative insults to cell death mechanisms in models of als. 11754998 - Chemokines and alzheimer's disease. 20390378 - Arsenite-induced apoptosis is prevented by selenite in a375 cell line. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Asian Pacific journal of tropical medicine Volume: 5 ISSN: 1995-7645 ISO Abbreviation: Asian Pac J Trop Med Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101533720 Medline TA: Asian Pac J Trop Med Country: Singapore |
Other Details:
|
Languages: eng Pagination: 136-41 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Istana, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anti-arthritis activity of roots of Hemidesmus indicus R.Br. (Anantmul) in rats.
Next Document: Antibacterial potential of sponge endosymbiont marine Enterobacter sp at Kavaratti Island, Lakshadwe...